2010 Fiscal Year Final Research Report
The basic research for elucidation of molecular mechanism of the prostate cancer recurrence and the treatment strategy construction
| Project/Area Number |
20390421
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAMIKI Mikio Kanazawa University, 医学系, 教授 (70155985)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOKAMI Atsushi 金沢大学, 附属病院, 講師 (50248580)
KYO Satoru 金沢大学, 医学系, 講師 (50272969)
HIGASHI Tatuya 静岡県立大学, 薬学部, 准教授 (90272963)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前立腺癌 / DHEA / 間質細胞 / トラニラスト / CTEN / パクリタキセル耐性 |
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| Research Abstract |
1. Adrenal androgen, DHEA, is important for recurrence of prostate cancer. Prostate cancer stromal cells and prostate cancer cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA. 2. Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses TGF-β-associated osteoblastic changes. 3. We identified CTEN, one of important genes that is associated with paclitaxel resistance. Expression of CTEN recovered paclitacel-resistance.
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