2010 Fiscal Year Final Research Report
Drug development using novel animal model based on the pathogenesis of Parkinson' s disease-related disorders
| Project/Area Number |
20406005
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHTA Shigeru 広島大学, 大学院・医歯薬学総合研究科, 教授 (60160503)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIHARA Kazumi 広島国際大学, 薬学部, 准教授 (20271067)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 熱帯風土病 / パーキンソン病関連疾患 / イソキノリンアルカロイド / P糖タンパ |
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| Research Abstract |
We identified the structures of about 10 compounds in Annona muricata, which is a candidate for environmental factors involved in the pathogenesis of Parkinson' s disease-related disorders. Among them, a tetrahydroisoquinoline derivative induced an abnormal accumulation of some proteins and endoplasmic reticulum stress.
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Research Products
(33 results)
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[Journal Article] 1-Benzyl-1, 2, 3, 4-tetrahydroisoquinolinebinds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination2010
Author(s)
Kohta R, Kotake Y, Hosoya T, HiramatsuT, Otsubo Y, Koyama H, Hirokane Y, YokoyamaY, Ikeshoji H, Oofusa K, Suzuki M, Ohta S.
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Journal Title
J Neurochem
Volume: 114
Pages: 1291-1301
Peer Reviewed
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[Journal Article] Approach for invivo protein binding of 5-n-butylpyrazolo[ 1, 5-a] pyrimidine bioactivated in chimeric mice with humanized liver bytwo-dimensional electrophoresis with accelerator mass spectrometry2010
Author(s)
Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
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Journal Title
Chem ResToxicol
Volume: 23
Pages: 152-158
Peer Reviewed
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