2010 Fiscal Year Final Research Report
The genomic epidemiology and immunological cohort study on amoebiasis in South Asia
| Project/Area Number |
20406008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyushu University |
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Principal Investigator |
HAMANO Shinjiro Kyushu University, 熱帯医学研究所, 教授 (70294915)
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| Co-Investigator(Kenkyū-buntansha) |
HISAEDA Hajime 九州大学, 医学研究院, 准教授 (50243689)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 南アジア / 感染症 / 赤痢アメーバ症 / ゲノム疫学 / コホート研究 |
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| Research Abstract |
We have carried out the genomic epidemiology and immunological cohort study on amoebiasis in Bangladesh and found that Entamoeba moshkovskii was prevalent in Bangladesh. E. moshkovskii is morphologically indistinguishable from pathogenic E. histolytica and non-pathogenic Entamoeba dispar. As E. moshkovskii has been considered to be a non-pathogenic or a free living amoeba, there are few studies to elucidate the pathogenicity of it. Thus, we carried out the study to clarify the pathogenicity of E. moshkovskii. The prevalence of each Entamoeba spp. in diarrheal episode was examined in Bangladesh and several cases that were positive only for E. moshkovskii but negative for other conceivable diarrhea-causative microbes were found. E. moshkovskii was found to be pathogenic to mice and to well associate with diarrheal episode in Bangladeshi children. Therefore it is important to re-estimate the pathogenicity of E. moshkovskii.
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[Journal Article] Involvement of CD8(+) T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain.2010
Author(s)
Imai T., Shen J., Chou B., Duan X., Tu L., Tetsutani K., Moriya C., Ishida H., Hamano S., Shimokawa C., Hisaeda H., Himeno K.
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Journal Title
Eur.J.Immunol. 40(4)
Pages: 1053-1061
Peer Reviewed
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[Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010
Author(s)
Ishida H., Matsuzaki-Moriya C., Imai T., Yanagisawa K., Nojima Y., Suzue K., Hirai M., Iwakura Y., Yoshimura A., Hamano S., Shimokawa C., Hisaeda H.
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Journal Title
Biochem.Biophys.Res.Commun. 402(4)
Pages: 790-795
Peer Reviewed
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[Journal Article] Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α (WSX-1).2008
Author(s)
Sugiyama N., Nakashima H., Yoshimura T., Sadanaga A., Shimizu S., Masutani K., Igawa T., Akahoshi M., Miyake K., Takeda A., Yoshimura A., Hamano S., Yoshida H.
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Journal Title
Ann.Rheum.Dis. 67
Pages: 1461-1467
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[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T Cells.2008
Author(s)
Hisaeda H., Tetsutani K., Imai T., Moriya C., Tu L., Hamano S., Duan X., Chou B., Ishida H., Aramaki A., Shen J., Ishii K.J., Coban C., Akira S., Takeda K., Yasutomo K., Torii M., Himeno K.
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Journal Title
J.Immunol. 180
Pages: 2496-2503
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[Presentation] A study on the pathogenicity of Entamoeba moshkovskii2011
Author(s)
Chikako Shimokawa, Mamum Kabir, Mami Taniuchi, Dinesh Mondal, Seiki Kobayashi, Ibne karim M.Ali, Masachika Senba, Eric Hoput, Haque Rashidul, William A. Petri Jr., 濱野真二郎
Organizer
第4回原虫感染免疫研究会
Place of Presentation
長崎大学医学部ポンペ会館
Year and Date
2011-02-04
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