2010 Fiscal Year Final Research Report
Epidemiological and virological studies on avian influenza virus H5N1 in Egypt
| Project/Area Number |
20406025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Osaka University |
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Principal Investigator |
IKUTA Kazuyoshi Osaka University, 微生物病研究所, 教授 (60127181)
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| Co-Investigator(Kenkyū-buntansha) |
SAKUDO Akikazu 琉球大学, 医学部・保健学科, 助教 (10397672)
NAKAYA Takaaki 大阪大学, 微生物病研究所, 准教授 (80271633)
TAKAHASHI Kazuo 大阪府立公衆衛生研究所, 副所長 (10171472)
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| Co-Investigator(Renkei-kenkyūsha) |
OKUNO Yoshinobu (財)阪大微生物病研究会, 観音寺研究所, 所長 (30112064)
KOKETSU-KUBOTA Ritsuko (財)阪大微生物病研究会, 研究員 (80467521)
WATANABE Yohei 大阪大学, 微生物病研究所, 特任研究員 (50452462)
SASAKI TADAHIRO 大阪大学, 微生物病研究所, 特任研究員 (20547533)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 鳥インフルエンザウイルス / エジプト / アレキサンドリア大学 / ニワトリ / アヒル / ハト / 遺伝子配列 / 病原性 |
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| Research Abstract |
Highly pathogenic avian influenza A virus (HPAIV H5N1) is currently widespread in several areas. Although the current H1N1 pandemic may have diverted attention from the continuing worldwide circulation of H5N1 virus, the pandemic threat of H5N1 is still alarming. In particular, Egypt has unexpectedly had the highest number of human cases of H5N1 infection. In this study, we conducted a molecular-epidemiological studies using H5N1 viruses isolated between 2006 and 2008-2009 in Egypt. The phylogenetic results showed that recent human isolates clustered into several new H5 sublineages. As expected, we found that these H5 sublineages have acquired an enhanced binding affinity for α2, 6SA.
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Research Products
(28 results)
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[Journal Article] Development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza A virus H1N1 Clin.2011
Author(s)
Mizuike R, Sasaki T, Baba K, Iwamoto H, Shibai Y, Kosaka M, Kubota-Koketsu R, Yang C-S, Du A, Sakudo A, Tsujikawa M, Yunoki M, Ikuta K
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Journal Title
Vaccine Immunol. 18
Pages: 494-499
Peer Reviewed
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[Journal Article] Highly conserved sequences for human neutralization epitope on hema.gglutinin of influenza A viruses H3N2, H1N1 and H5N1 : Implication for humanmonoclonal antibody recognition.2010
Author(s)
Yamashita A, Kawashita N, Kubota-Koketsu R, Inoue Y, Watanabe Y, Ibrahim MS, Ideno S, Yunoki M, Okuno Y, Takagi T, Yasunaga T, Ikuta K
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Journal Title
Biochem.Biophys.Res.Commun. 393
Pages: 614-618
Peer Reviewed
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[Journal Article] Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach.2009
Author(s)
Nakamura S, Yang CS, Sakon N, Ueda M, Tougan T, Yamashita A, Goto N, Takahashi K, Yasunaga T, Ikuta K, Mizutani T, Okamoto Y, Tagami M, Morita R, Maeda N, Kawai J, Hayashizaki Y, Nagai Y, Horii T, Iida T, Nakaya T
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Journal Title
Peer Reviewed
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[Journal Article] Anionic polymer2009
Author(s)
Sakudo A, Baba K, Tsukamoto M, Sugimoto A, Okada T, Kobayashi T, Kawashita N, Takagi T, Ikuta K
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Journal Title
poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus. Bioorg.Med.Chem. 17
Pages: 752-757
Peer Reviewed
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[Journal Article] Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody.2009
Author(s)
Du A, Daidoji T, Koma T, Ibrahim MS, Nakamura S, de Silva UC, Ueda M, Yang CS, Yasunaga T, Ikuta K, Nakaya T
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Journal Title
Biochem.Biophys.Res.Commun. 378
Pages: 197-202
Peer Reviewed
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