2010 Fiscal Year Final Research Report
Pharmaco-physiological studies related to the deterrence factor of activities during development
| Project/Area Number |
20500246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cognitive science
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
HONDA Yoshiko Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 主任研究員 (50142154)
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| Co-Investigator(Kenkyū-buntansha) |
USUI Setsuo 財団法人医学研究機構, 東京都神経科学総合研究所, 主任研究員 (30160253)
KODAMA Tohru 財団法人医学研究機構, 東京都神経科学総合研究所, 副参事研究員 (20195746)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 感情 / 情緒 / 行動 |
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| Research Abstract |
The rats grown under the condition of LD1:1 (repeated light-dark period every hour) show the hyperactivity in the unfamiliar place. This hyperactivity is related to the high amount of dopamine in the brain. Methylphenidate administration is effective for reduction of hyperactivities. D5 mRNA expression decreased significantly in the caudate nucleus of 6 week old LD1:1 rats. Furthermore, DAT mRNA expression showed abnormal in the frontal cortex of 3 week old LD1:1 rats.
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Research Products
(33 results)
