2010 Fiscal Year Final Research Report
Studies on novel mechanism of proteins that relate to migration and proliferation of neuronal cells
| Project/Area Number |
20500307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | University of Fukui |
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Principal Investigator |
YAGI Hideshi University of Fukui, 医学部, 准教授 (10303372)
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| Co-Investigator(Kenkyū-buntansha) |
XIE MinーJue 福井大学, 医学部, 助教 (40444210)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Makoto 福井大学, 医学部, 教授 (10222019)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経発生 / 分化 / 異常 |
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| Research Abstract |
Filip and Filip homologous proteins relate to migration and proliferation of neuronal cells. Analysis on the function of Filip and Filip homologous proteins revealed that one of cytoskeletal proteins binds to Filip and Filip homologous protein. We elucidated that Filip controls intracellular distribution of the cytoskeletal protein and identified a novel function of Filip in neuron.
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Research Products
(21 results)
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[Journal Article] LL5β directs the translocation of Filamin A and SHIP2 to sites of PtdIns(3,4,5)P3 accumulation and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.2010
Author(s)
Takabayashi, T., Xie, M.-J., Takeuchi, S., Kawasaki, M., Yagi, H., Okamoto, M., Tariqur, R.M., Malik, F., Kuroda, K., Kubota, C., Fujieda, S., Nagano, T., Sato, M.
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Journal Title
J.Biol.Chem. 285(21)
Pages: 16155-16165
Peer Reviewed
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[Journal Article] Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.2008
Author(s)
Hisahara, M., Chiba, S., Matsumoto, H., Tanno, M., Yagi, H., Shimohara, S., Sato, M., Horio, Y.
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Journal Title
Proc.Natl.Acad.Sci.(USA). 105(40)
Pages: 15599-15604
Peer Reviewed
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[Journal Article] Establishment of framework of the cortical area is influenced by Otx1.2008
Author(s)
Ando, K., Yagi, H., Suda, Y., Aizawa, S., Sakashita, M., Nagano, T., Terashima, T., Sato, M.
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Journal Title
Neurosci.Res. 60(4)
Pages: 457-459
Peer Reviewed
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