Neural activity related to construction of compound images in the macaque prefrontal cortex

2010 Fiscal Year Final Research Report

• Project/Area Number: 20500355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Niigata University
• Principal Investigator: HASEGAWA Isao Niigata University, 医歯学系, 教授 (60282620)
• Co-Investigator(Kenkyū-buntansha): TODA Haruo 新潟大学, 医歯学系, 講師 (10217507) ; IIJIMA Atsuhiko 新潟大学, 自然科学系, 助教 (00377186) ; KAWASAKI Keisuke 新潟大学, 医歯学系, 助教 (60511178)
• Project Period (FY): 2008 – 2010
• Keywords: 認知 / 記憶 / マカクザル / 前頭葉 / 電気生理 / 視覚 / 図形

Research Abstract

Japanese monkeys were trained in a symbolic construction matching-to-sample (SCMS) task in which 6 compound figures symbolically represent 6 objects. Behavioral experiments showed that the monkeys could learn the SCMS task, and generalize from item-object associations to category-object associations. We developed ultra-thin flexible electrode arrays for electrocorticogram (ECoG), and implanted them into the prefrontal cortex of the monkeys. During the SCMS task, ECoG responses to the second sample element was induced earlier and became larger than during sample presentation of a compound figure in a symbolic matching-to-sample task.

Research Products

• [Journal Article] Simultaneous recording of ECoG and intracortical neuronal activity using a flexible multichannel electrode-mesh in visual cortex (2011)
  • Author(s): Toda H, Suzuki T, Sawahata H, Majima K, Kamitani Y, Hasegawa I
  • Journal Title: Neuroimage 54 Pages: 203-212
  • Peer Reviewed
• [Journal Article] 前脳GABA(A)受容体とバゾプレッシン分泌 (2009)
  • Author(s): 山口賢一、山田貴穂、長谷川功
  • Journal Title: 生体の科学 60 Pages: 378-379
  • Peer Reviewed
• [Journal Article] 記憶を貯める脳、活かす脳 (2008)
  • Author(s): 長谷川功
  • Journal Title: 新潟医学会雑誌 122 Pages: 663-668
  • Peer Reviewed
• [Journal Article] 認知記憶の脳内表現とその活性化 (2008)
  • Author(s): 長谷川功、飯島淳彦、戸田春男
  • Journal Title: 新潟県医師会報 696 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols.
  • Author(s): Matsuo T, Kawasaki K, Osada T, Sawahata H, Suzuki T, Shibata M, Miyakawa N, Nakahara K, Iijima A,, Sato N, Kawai K, Saito N, Hasegawa I
  • Journal Title: Frontiers in Systems Neuroscience in press
  • Peer Reviewed
• [Journal Article] 前脳のGABA 受容体による自律機能の調節
  • Author(s): 山口賢一、山田貴穂、濱齊、渡辺賢一、長谷川功
  • Journal Title: 新潟医学会雑誌 in press Pages: 有
• [Presentation] Symmetry and generalization in visual-visual association learning in macaque monkeys (2010)
  • Author(s): Iijima A, Kawasaki K, Hatano Y, Fujisawa N, Hasegawa I.
  • Organizer: Soc Neurosci Abstr 36
  • Place of Presentation: San Diego USA(in press)
  • Year and Date: 2010-11-17
• [Presentation] Electrocorticography within the superior temporal sulcus of macaques (2010)
  • Author(s): Matsuo T, Kawasaki K, Sawahata H, Shibata M, Miyakawa N, Kawai K, Satou N, Saito N, Nakahara K,Suzuki T, Hasegawa I.
  • Organizer: Soc Neurosci Abstr 36,123,
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-16
• [Presentation] Symbolization of object categories by macaque monkeys (2010)
  • Author(s): Iijima A, Hatano Y, Fujisawa N, Hasegawa I.
  • Organizer: Neurosci Res 68 suppl,e180,2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] The basis of the EcoG signal in visual cortex (2010)
  • Author(s): Hasegawa I
  • Organizer: 2nd UK-Japan Workshop on the Brain-Machine Interface
  • Place of Presentation: Newcastle, UK
  • Year and Date: 2010-02-26
• [Presentation] Simultaneous recording of visual cortical response by a meshelectrode array and an intracortical microelectrode (2009)
  • Author(s): Toda H, Sawahata H, Suzuki T, Watanabe H, Isa T, Hasegawa I.
  • Organizer: Soc Neurosci Abstr 35,770.20
  • Place of Presentation: Chicago,USA
  • Year and Date: 20091017-20091021
• [Book] 局所フィールド電位の全脳同時記録(ブレインサイエンス・レビュー2010(編集))(ブレインサイエンス振興財団)(伊藤正男・川合述史) (2010)
  • Author(s): 長谷川功
  • Total Pages: 209-222
  • Publisher: (株)クバプロ
• [Patent(Industrial Property Rights)] 意志伝達支援装置 (2009)
  • Inventor(s): 長谷川功(寄与率70%)、神谷之康(同30%)
  • Industrial Property Rights Holder: 新潟大学/ATR
  • Industrial Property Number: 特許願,P09-0315
  • Filing Date: 2009-04-27
• [Patent(Industrial Property Rights)] 網状生体電極アレイ (2009)
  • Inventor(s): 長谷川功(寄与率60%)、鈴木隆文(同40%)
  • Industrial Property Rights Holder: 新潟大学/東京大学
  • Industrial Property Number: 特許願,NIU09001
  • Filing Date: 2009-07-30