2010 Fiscal Year Final Research Report

Effects of prolyl hydroxylase inhibitor treatment on oxygen sensing mechanism in skeletal muscles

Research Project

Project/Area Number	20500571
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Sports science
Research Institution	Hokkaido University of Education
Principal Investigator	SUZUKI Junichi Hokkaido University of Education, 教育学部, 准教授 (80261379)
Project Period (FY)	2008 – 2010
Keywords	スポーツ生理学 / 運動生理学 / 酸素センシング機構
Research Abstract	Recently a family of O2-dependent prolyl hydroxylase domain-containing enzymes has been identified as a cellular oxygen sensing mechanism. Reduced prolyl hydroxylase activity facilitates an accumulation of hypoxia-inducible factor (HIF-1alpha). This study was designed to examine the effects of prolyl hydroxylase inhibitor, supplementation on muscle oxygen sensing mechanism. The present results suggest that prolyl hydroxylase inhibitor facilitates capillary angiogenesis and glycolytic enzyme activity via HIF-1alpha upregulation in hind-leg muscles.

(4 results)