2010 Fiscal Year Final Research Report
REGULATION AND MODIFICATION OF EXERCISE-STIMULATED AMP-KINASE IN SKELETAL MUSCLE
| Project/Area Number |
20500576
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kyoto University |
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Principal Investigator |
HAYASHI Tatsuya Kyoto University, 大学院・人間・環境学研究科, 准教授 (00314211)
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| Co-Investigator(Renkei-kenkyūsha) |
MORITANI Toshio 京都大学, 大学院・人間・環境学研究科, 教授 (90175638)
FUSHIKI Toru 京都大学, 大学院・農学研究科, 教授 (20135544)
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| Project Period (FY) |
2008 – 2010
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| Keywords | AMPキナーゼ / 骨格筋 / 運動 / 糖代謝 / エネルギー代謝 / シグナル伝達 |
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| Research Abstract |
Physical exercise stimulates 5' -AMP-activated protein kinase (AMPK), an enzyme that chemically adds phosphate groups to specific proteins in human and animal skeletal muscle. AMPK is important for promoting glucose, lipid and energy utilization in skeletal muscle cells. We found evidence suggesting that leucine, a branched chain amino acid, enhances exercise-stimulated AMPK activity, and that anti-diabetic plant (extract of Mulberry leaf) and anti-diabetic compounds (caffeine, berberine) increase AMPK activity in rat skeletal muscle. We also analyzed underlying molecular mechanisms.
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