The relation between effect of passive smoking on immune system in the lung and lung carcinogenesis

2010 Fiscal Year Final Research Report

• Project/Area Number: 20500606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kyoto Sangyo University
• Principal Investigator: TAKEUCHI Minoru Kyoto Sangyo University, 総合生命科学部, 教授 (70257773)
• Project Period (FY): 2008 – 2010
• Keywords: 受動喫煙 / 副流煙 / 肺胞マクロファージ / 免疫機能 / DNA損傷 / 副流煙水溶性抽出物 / 肺癌 / 発癌

Research Abstract

Side-stream tobacco smoke(STS) increased the number and ROS productions of AM. Phagocytic activity, expressions of TNF-αmRNA and TLRs were inhibited by STS. STS induced DNA damage in AM. STS was a risk factor for DNA damage of AM and inhibited the immunological functions in AM mediated by DNA damage. The inhibition of immunological functions in AM by STS may be associated with carcinogenesis in the lung.

Research Products

• [Journal Article] Interleukin-28B acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma. (2011)
  • Author(s): Koichiro Yoshimoto, Tsunao Kishida, Hiroshi Nakano, Masahiro Matsui, Masaharu Shin-Ya, Taketoshi Shimada, Shigeru Nakai, Jiro Imanishi, Minoru Takeuchi, Yasuo Hisa, Osam Mazda.
  • Journal Title: Journal of Immunotherapy. 34(2) Pages: 139-48
  • Peer Reviewed
• [Journal Article] Pinkerton and 竹内実, Effect of Jungle honey on chemotactic activity of neutrophils. (2010)
  • Author(s): Mayuko Miyagawa, Miki Fukuda, Yuriko Hirono, Ayaka Kawazoe, Eri Shigeyoshi, Masaaki Sakura, Toru Takeuchi, Osamu Mazda, Kent E.
  • Journal Title: Journal of ApiProduct and ApiMedical Science. 2(4) Pages: 149-154
  • Peer Reviewed
• [Journal Article] タバコ主流煙による肺胞マクロファージのDNA損傷の誘導とアポトーシスの制御 (2010)
  • Author(s): 廣野由里子、竹内実
  • Journal Title: 京都産業大学論集、自然科学系列 第39号 Pages: 63-93
  • Peer Reviewed
• [Journal Article] Jungle Honey Enhances Immune Function and Antitumor Activity. (2009)
  • Author(s): Fukuda M, Kobayashi K, Hirono Y, Miyagawa M, Ishida T, Ejiogu EC, Sawai M, Pinkerton KE, Takeuchi M
  • Journal Title: Evid Based Complement Alternat Med.
  • Peer Reviewed
• [Journal Article] Inhibition of immunological function mediated DNA damage of alveolar macrophages caused by cigarette smoke in mice. (2009)
  • Author(s): Ishida T, Hirono Y, Yoshikawa K, Hutei Y, Miyagawa M, Sakaguchi I, Pinkerton KE, Takeuchi M
  • Journal Title: Inhal Toxicol. Dec;21(14) Pages: 1229-35
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone increased oxidative stress in a human cell line during differentiation. (2009)
  • Author(s): Izumo K, Horiuchi M, Komatsu M, Aoyama K, Bandow K, Matsuguchi T, Takeuchi M, Takeuchi T
  • Journal Title: Free Radic Res. Oct;43(10) Pages: 922-31
  • Peer Reviewed
• [Journal Article] Alveolar macrophage from cigarette smoke-exposed mice inhibits Blymphocyte proliferation stimulated with LPS. (2009)
  • Author(s): Ishida T, Pinkerton KE, Takeuchi M
  • Journal Title: Respiration. 77(1) Pages: 91-5
  • Peer Reviewed
• [Journal Article] ジャングルハニーによる免疫機能への影響と抗腫瘍作用 (2009)
  • Author(s): 福田美樹、宮川真由子、竹内実
  • Journal Title: 京都産業大学論集、自然科学系列 第38号 Pages: 95-118
  • Peer Reviewed
• [Journal Article] Pinkerton. Acute Tobacco Smoke-Induced Airways Inflammation in Spontaneously Hypertensive Rats. (2008)
  • Author(s): Bei Yu, Urmila P., Kodavanti, Minoru Takeuchi, Hanspeter Witschi, Kent E.
  • Journal Title: Inhalation toxicology 20 Pages: 623-633
  • Peer Reviewed
• [Journal Article] Environmental mutagens may be implicated in emergence of drug-resistant microorganisms.
  • Author(s): Miyahara, Emiko, Nishie, Makiko, Takumi, Shota, Miyanohara, Hiroaki, Nishi, Junichiro, Yoshiie, Kiyotaka, Oda, Hiroshi, Takeuchi, Minoru, Komatsu, Masaharu, Aoyama, Kohji, Horiuchi, Masahisa, Takeuchi, Toru.
  • Journal Title: FEMS Microbiology Letters In press
  • Peer Reviewed
• [Journal Article] Jungle honey enhances immune function and antitumor activity.
  • Author(s): Fukuda M, Kobayashi K, Hirono Y, Miyagawa M, Ishida T, Ejiogu EC, Sawai M, Pinkerton KE, Takeuchi M.
  • Journal Title: Evid Based Complement Alternat Med. In press
  • Peer Reviewed
• [Presentation] Effect of Environmental Tobacco Smoke Exposure to Alveolar Macrophage Associated with Innate Immunity in the Lung. (2011)
  • Author(s): Minoru Takeuchi, Shinichi Inoue, Yuriko Hirono, Mayuko Miyagawa, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E.Pinkerton.
  • Organizer: 6th World Congress on Pediatric Critical Care
  • Place of Presentation: Sydney
  • Year and Date: 20110313-20110317
• [Presentation] LPS経鼻投与による肺炎症の誘導と好中球機能について (2010)
  • Author(s): 川添彩香、重吉瑛里、佐倉正明、廣野由里子、宮川真由子、竹内実
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20101125-20101127
• [Presentation] アガリクス茸熱水抽出液による好中球の走化活性とその有効成分 (2010)
  • Author(s): 宮川真由子、川添彩香、重吉瑛里、廣野由里子、佐倉正明、竹内亨、ピンカートンケント、竹内実
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20101125-20101127
• [Presentation] 蜂蜜による抗体産生機能への影響 (2010)
  • Author(s): 重吉瑛里、川添彩香、廣野由里子、宮川真由子、佐倉正明、竹内実
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20101125-20101127
• [Presentation] タバコ主流煙による肺胞マクロファージのDNA損傷とその修復 (2010)
  • Author(s): 廣野由里子、宮川真由子、佐倉正明、川添彩香、重吉瑛里、稲賀すみれ、松田修、長井苑子、竹内亨、ケント・ピンカートン、竹内実
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 20101125-20101127
• [Presentation] Induction of neutrophils in LL/2 tumor bearing mice (2010)
  • Author(s): Mayuko Miyagawa , Ayaka Kawazoe, Eri Shigeyosi, Yuriko Hirono, Sakura Masaaki, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 20100922-20100924
• [Presentation] Hotwater extract of Agaricus blazei Murill (ABM) prevents the ageing process by activation of neutrophil functions (2010)
  • Author(s): Mayuko Miyagawa, Ayaka Kawazoe, Eri Shigeyosi, Yuriko Hirono, Sakura Masaaki ,Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
  • Organizer: The 1st International Congress on Controversies in Longevity, Health and Aging
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100624-20100627
• [Presentation] Cigarette Smoke Induces DNA Damage but not Apoptosis in Alveolar Macrophages. (2010)
  • Author(s): Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Masaaki Sakura, Sumire Inaga, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
  • Organizer: ATS 2010 International Conference
  • Place of Presentation: New Orleans, Louisiana
  • Year and Date: 20100514-20100519
• [Presentation] Effects of jungle honey on immune functions and anti-tumor activity (2010)
  • Author(s): 竹内実
  • Organizer: 2nd ICMUH
  • Place of Presentation: Kota Bharu
  • Year and Date: 2010-01-14
• [Presentation] EFFECT OF HOTWATER EXTRACT FROM AGARICUS BLAZEI MURILL ON IMMUNE FUNCTIONS (2009)
  • Author(s): M Miyagawa, Y Hirono, S Inoue, T Ishida, M Sakura, Y Hoshishima, T Takeuchi, KE Pinkerton, M Takeuchi
  • Organizer: XXI World Allergy Congress
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 20091206-20091210
• [Presentation] Effect of Side-stream Tobacco Smoke on DNA Damage in Alveolar Macrophage. (2009)
  • Author(s): Shinichi Inoue, Yuriko Hirono, Mayuko Miyagawa, Takahiro Ishida, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E. Pinkerton, Minoru Takeuchi
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] The mechanism of anti-tumor activity in induced immune cells by hot water extract from Agaricus blazei Murill. (2009)
  • Author(s): Mayuko Miyagawa, Shinichi Inoue, Hirono Yuriko, Takahiro Ishida, Masaaki Sakura, Toru Takeuchi, Yuichi Hoshishima, Kent E.Pinkerton, Minoru Takeuchi
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] Repair of DNA Damage in Alveolar Macrophages Induced by Cigarette Smoke Exposure. (2009)
  • Author(s): Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Sumire Inaga, Tomonori Naguro, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] The mechanism of inhibition of immune function in Alveolar Macrophage (AM) by smoking. (2009)
  • Author(s): M Takeuchi, Y Hirono, M Miyagawa, S Inoue, T Ishida, S Nagai, K E Pinkerton
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Year and Date: 20090612-20090614
• [Presentation] Neonatal Murine Sensitivity to Influenza Infection Is Enhanced by Perinatal Exposure to Environmental Tobacco Smoke. (2009)
  • Author(s): A.Ross, M.S, K.E.Pinkerton, Ph.D., M.Takeuchi, D.V.M
  • Organizer: ATS 2009 International Conference
  • Place of Presentation: San Diego, California
  • Year and Date: 20090515-20090520
• [Presentation] Inhibition of immunological functions in alveolar macrophages (AM) related with DNA damage by cigarette tobacco smoke exposure. (2009)
  • Author(s): M Takeuchi, Y Hirono, M Miyagawa, S Inoue, T Ishida, S Inaga, T Naguro, T Takeuchi, S Nagai, K E pinkerton
  • Organizer: ATS 2009 International Conference
  • Place of Presentation: San Diego, California
  • Year and Date: 20090515-20090520
• [Presentation] 竹内実副流煙による肺胞マクロファージのDNA損傷への影響 (2008)
  • Author(s): 井上慎一、廣野由里子、宮川真由子、石田喬裕、松田修、長井苑子、竹内亨、K.E.Pinkerton
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20081201-20081203
• [Presentation] Cigarette smoke induced DNA damage, but not apoptosis of alveolar macrophages. (2008)
  • Author(s): HIRONO Yuriko, INOUE Shinichi, MIYAGAWA Mayuko, MAZDA Osamu, NAGAI Sonoko, TAKEUCHI Toru, PINKERTON K.E, TAKEUCHI Minoru
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20081201-20081203
• [Presentation] Effect of hotwater extract from Agaricus blazei Murill on chemotaxis of neutrophils. (2008)
  • Author(s): Mayuko Miyagawa, Yuriko Hirono, Shinich Inoue, Takahiro Ishida, Osamu Mazda, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20081201-20081203
• [Presentation] Cigarette smoke induces DNA damage and inhibition of apoptosis in alveolar macrophages. (2008)
  • Author(s): Hirono Yuriko, Inoue Shinichi, Miyagawa Mayuko, Asada Hidetsugu, Mazda Osamu, Nagai Sonoko, Takeuchi Toru, Pinkerton K.E, Takeuchi Minoru
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Effect of hot water extract from Agaricus blazei Murill on immue functions and anti-tumor activity. (2008)
  • Author(s): Mayuko Miyagawa, Yuriko Hirono, Shinich Inoue, Hidetugu Asada, Osamu Mazda, Toru Takeuchi, K.E.Pinkerton, Minoru Takeuchi
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] タバコ主流煙による肺胞マクロファージ機能の抑制機構について (2008)
  • Author(s): 竹内実、石田喬裕、廣野由里子、小林健悟、宮川真由子、井上慎一、竹内亨、Kent E.Pinkerton
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 20080924-20080926
• [Presentation] 喫煙による肺胞マクロファージのDNA損傷の誘導とアポトーシスの抑制 (2008)
  • Author(s): 廣野由里子、小林健悟、福田美樹、宮川真由子、松田修、浅田秀基、長井苑子、竹内亨、K.E.Pinkerton、竹内実
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸
  • Year and Date: 20080615-20080617
• [Presentation] Cigarette Smoke Inhibits Antibody Production-Associated with Alveolar Macrophage. (2008)
  • Author(s): M.Takeuchi, K.kobayashi, Y.Hirono, S.Nagai, K.E.Pinkerton
  • Organizer: ATS 2008 International Conference
  • Place of Presentation: Tronto, Canada
  • Year and Date: 20080516-20080521
• [Remarks] ホームページ等
  • URL: http://www.cc.kyoto-su.ac.jp/~mtakex/