2010 Fiscal Year Final Research Report
Long-term voluntary exercise improves the efficacy of cerebral angiogenesis and neurogenesis in stroke-prone genetically hypertensive rats
| Project/Area Number |
20500636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kinki University |
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Principal Investigator |
NIWA Atsuko Kinki University, 医学部, 講師 (60122082)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHINO Hideaki 近畿大学, 医学部, 教授 (40122098)
NAKAMURA Kyoko 近畿大学, 医学部, 助教 (10512197)
SAKAUE Hiroshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60372645)
OOSHIMA Kana 近畿大学, 医学部, 助手 (60278653)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 運動処方と運動療法 / 脳血管障害 / 血管内皮前駆細胞 / 血管新生 / 神経新生 |
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| Research Abstract |
Beneficial effects of long-term exercise (EX) may relate to increase endothelial and hematopoietic progenitors, and neuronal stem cells. In EX SHRSP, the number and activity of EPC and hematopoietic cells in bone marrow and peripheral blood cells were increased before and after stroke. The numbers of microvessels and neuronal stem cells around cerebral lesion were increased in EX, coincident with the appearance of EPC. Furthermore, levels of CXCL12, VEGF, and BDNF were higher in the plasma and cerebral homogenates of EX rats than sedentary rats and the signaling molecules, ERK and CREB, were also up-regulated in EX rats.
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