2010 Fiscal Year Final Research Report
Study for the development of a novel treatment to prevent atherosclerosis with guava tea
| Project/Area Number |
20500713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
TAKAHASHI Yoshitaka Okayama Prefectural University, 保健福祉学部, 教授 (10236333)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Yuki 岡山県立大学, 保健福祉学部, 助教 (30453202)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 12-リポキシゲナーゼ / アラキドン酸 / 酸化LDL / 動脈硬化 / グアバポリフェノール / グアバ葉 |
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| Research Abstract |
Oxidative modification of low density lipoprotein (LDL) is one of the critical steps for the development of atherosclerosis and leukocyte-type 12-lipoxygenase has been suggested to play an essential role in this process. In this study, we demonstrated that guava leaf extracts inhibited not only the leukocyte-type 12-lipoxygenase activity but also LDL oxidation mediated by the enzyme-overexpressing J774A.1 cells. Oral administration of guava leaf extracts to apo E-knockout mice significantly reduced the area of atherogenic lesions developed in the aorta and aortic sinus. The major components inhibiting leukocyte-type 12-lipoxygenase contained in guava leaf extracts were identified as ethyl gallate and quercetin.
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Author(s)
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Author(s)
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Author(s)
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Pages: 570-576
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