2010 Fiscal Year Final Research Report
Study on functional antisense nucleic acids for ncRNA
| Project/Area Number |
20550147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Gunma University |
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Principal Investigator |
OZAKI Hiroaki Gunma University, 大学院・工学研究科, 教授 (90211820)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Yusuke 群馬大学, 大学院・工学研究科, 准教授 (90304302)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 核酸 / アンチセンス / siRNA |
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| Research Abstract |
Functional oligonucleotides were prepared for new antisense molecule to regulate microRNA. Incorporation of arabinonucleosides or phenanthroline-polyamine derivatives in DNA did not contribute to enhancement of antisense activity. siRNA bearing modified nucleoside was more active in silencing the gene expression. These siRNA could regulate the microRNA.
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