2010 Fiscal Year Final Research Report
Notochord-Neuron interaction during the chordate evolution.
| Project/Area Number |
20570214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
TAKAHASHI Hiroki National Institute for Basic Biology, 形態形成研究部門, 助教 (40283585)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脊索 / 神経 / 発生 / 進化 |
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| Research Abstract |
The midline organ notochord and its overlying dorsal neural tube are the most prominent features of the chordate body plan. Although molecular mechanisms involved in the dorsal patterning of the nervous system have been studied extensively in vertebrate embryos, none of the genes that are expressed specifically in notochord cells have been shown to function in this process. Here, we report a gene in the urochordate Ciona intestinalis encoding a fibrinogen-like protein that plays a pivotal role in the notochord-dependent dorsal positioning of neuronal cells. Therefore, it is highly likely that the interaction of the notochord-based fibrinogen-like protein and the neural tube-based Notch signaling is essential for the dorsal patterning of the nervous system or for the establishment of the chordate body plan.
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[Journal Article] CIPRO 2.5 : Ciona intestinalis Protein Database, a unique integrated repository of large-scale omics data, bioinformatic analyses, and curated annotation, with user rating and reviewing functionality.2011
Author(s)
Endo T., Ueno K., Yonezawa K., Mineta K., Hotta K., Satou Y., Yamada L., Ogasawara M., Takahashi H., Nakajima A., Nakachi M., Nomura M., Yaguchi J., Sasakura Y., Yamasaki C., Sera M., Yoshizawa A., Imanishi T., Taniguchi H., Inaba K.
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Journal Title
Nucleic Acids Res. 38
Pages: D807-814
Peer Reviewed
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