2010 Fiscal Year Final Research Report
Activation balance of nuclear receptors ERα and CAR regulates hepatic lipid metabolism
Project/Area Number |
20580318
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
YAMAMOTO Yukio Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (40321707)
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Co-Investigator(Kenkyū-buntansha) |
亀井 康富 東京医科歯科大学, 難治疾患研究所, 准教授 (70300829)
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Project Period (FY) |
2008 – 2010
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Keywords | エストロゲン / エストロゲンレセプター / 脂質代謝 / 核内受容体 |
Research Abstract |
The underlying molecular mechanism of the sex difference in lipid metabolism remains largely unknown. We investigate the roles of hepatic nuclear receptors : ERα (Estrogen Receptor α), which is an authentic estrogen receptor, and LXR (Liver X Receptor) and CAR(Constitutive Androstane/Active Receptor), which are regulators of hepatic lipid metabolism. The transcriptional crosstalk between LXR, CAR, and ERα may explain the suppression mechanism of lipid synthesis by estrogens.
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[Journal Article] In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid.2008
Author(s)
Yamada H, Yoshida M, Nakano Y, Suganami T, Satoh N, Mita T, Azuma K, Itoh M, Yamamoto Y, Kamei Y, Horie M, Watada H, Ogawa Y.
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Journal Title
Arterioscler Thromb Vasc Biol. 28
Pages: 2173-2179
Peer Reviewed
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