2010 Fiscal Year Final Research Report
The mechanism elucidation of the protective effect of prostanoids in ischemic myocardial protection
| Project/Area Number |
20590244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
YUHKI Koh-Ichi Asahikawa Medical College, 医学部, 講師 (80302420)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プロスタノイド / プロスタグランジンE_2 / 心筋梗塞 / プレコンディショニング / 受容体欠損マウス |
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| Research Abstract |
Prostanoids are bioactive lipid mediators consisting of prostaglandins (PGs) and thromboxanes. On the other hand, Ischemic preconditioning (IPC) is a phenomenon that a brief ischemia of the heart induces a potent cardioprotective mechanism upon a succeeding ischemic insult. This research was analyzed about the roles of prostanoids in the ischemic heart disease using mice lacking PGE_2 receptor. We demonstrated that the PGE_2-EP_4 system exerts the cardio-protective effect in the late phase of IPC partly by augmenting the anti-apoptosis related signaling.
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[Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation.2010
Author(s)
Kuriyama S, Kashiwagi H, , Yuhki K, Kojima F, Yamada T, Fujino T, Hara A, Takayama K, Maruyama T, Yoshida A, Narumiya S, Ushikubi F
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Journal Title
Thromb.Haemost. 104
Pages: 796-803
Peer Reviewed
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