2010 Fiscal Year Final Research Report
Metabolic and Kinetic Study of D-Aspartate-Containing Protein Caused by Oxidative Stress
| Project/Area Number |
20590278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
KINOUCHI Tadatoshi Kyoto University, 原子炉実験所, 講師 (90301457)
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| Project Period (FY) |
2008 – 2010
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| Keywords | D-アミノ酸 / フォールディング病 / タンパク質分解酵素 / 酸化ストレス / ミトコンドリア / 老化 / ラセミ化 |
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| Research Abstract |
The formation and accumulation of D-aspartate residue (D-Asp) in proteins caused by oxidative stress leads to denaturation of proteins, and is consequently responsible for aging-related misfolding diseases such as Alzheimer's disease. We sought to identify that an unknown protease selectively degrades the D-Asp-containing protein, namely D-aspartyl endopeptidase (DAEP), and finally purified it. DAEP therefore seems to physiologically serve as the quality control system against the noxious D-Asp-containing protein in the long life span of mammals.
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