2010 Fiscal Year Final Research Report
Gene expression profiling to identify molecular network for seasonal allergic rhinitis
| Project/Area Number |
20590327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NOGUCHI Emiko University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (40344882)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Kazuhiko 筑波大学, 大学院・人間総合科学研究科, 准教授 (90211078)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 花粉症 / マイクロアレイ / プロテオーム |
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| Research Abstract |
We performed microarray analysis and proteomics to identify genes/proteins related to seasonal allergic rhinitis (SAR). We found that IL17RB was significantly up-regulated during natural exposure against Japanese ceder pollens in patients with SAR. Also, we identified that apolipoprotein A4 was significantly up-regulated in SAR patients treated by sublingual immunotherapy compared with those treated with placebo.
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Research Products
(43 results)
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[Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma2011
Author(s)
Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M
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Journal Title
Am J Respir Cell Mol Biol 44
Pages: 787-93
Peer Reviewed
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[Journal Article] Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis2010
Author(s)
Makino Y, Noguchi E, Takahashi N, Matsumoto Y, Kubo S, Yamada T, Imoto Y, Ito Y, Osawa Y, Shibasaki M, Uchida K, Meno K, Suzuki H, Okubo K, Arinami T, Fujieda S
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Journal Title
J Allergy Clin Immunol 126
Pages: 1163-9
Peer Reviewed
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[Journal Article] Supportive evidence for reduced expression of GNB1L in schizophrenia2010
Author(s)
Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Schizophr Bull 36
Pages: 756-765
Peer Reviewed
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[Journal Article] S2554X mutation in the filaggrin gene is associated with allergen sensitization in the Japanese population2010
Author(s)
Imoto Y, Enomoto H, Fujieda S, Okamoto M, Sakashita M, Susuki D, Okada M, Hirota T, Tamari M, Ebe K, Arinami T, Noguchi E.
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Journal Title
J Allergy Clin Immunol 125
Pages: 498-500, e492
Peer Reviewed
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[Journal Article] SMAD3 as an atopic dermatitis susceptibility gene in the Japanese population2009
Author(s)
Otsuka K, Takeshita S, Enomoto H, Takahashi T, Hirota T, Tamari M, Ebe K, Otsuka F, Shibasaki M, Arinami T, Noguchi E.
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Journal Title
J Dermatol Sci 55
Pages: 200-202
Peer Reviewed
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[Journal Article] Associations between decay-accelerating factor polymorphisms and allergic respiratory diseases2009
Author(s)
Kawai T, Takeshita S, Imoto Y, Matsumoto Y, Sakashita M, Suzuki D, Shibasaki M, Tamari M, Hirota T, Arinami T, Fujieda S, Noguchi E.
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Journal Title
Clin Exp Allergy 39
Pages: 1508-14
Peer Reviewed
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[Journal Article] Large scale genotyping study for asthma in the Japanese population2009
Author(s)
Imada Y, Fujimoto M, Hirata K, Hirota T, Suzuki Y, Saito H, Matsumoto K, Akazawa A, Katsunuma T, Yoshihara S, Ebisawa M, Shibasaki M, Arinami T, Tamari M, Noguchi E.
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Journal Title
BMC Res Notes 2
Pages: 54
Peer Reviewed
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[Journal Article] Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells2009
Author(s)
Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Ziegler SF, Tamari M
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Journal Title
Am J Respir Cell Mol Biol 40
Pages: 368-374
Peer Reviewed
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[Journal Article] Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation2008
Author(s)
Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, Makino Y, Hirata K, Matsumoto Y, Arinami T, Noguchi E.
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Journal Title
Proteomics Clin Appl 2
Pages: 46-54
Peer Reviewed
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[Journal Article] Supportive evidence for reduced expression of GNB1L in schizophrenia2008
Author(s)
Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Peer Reviewed
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[Journal Article] Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population2008
Author(s)
Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, Saito H, Nakamura Y, Tamari M
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Journal Title
J Allergy Clin Immunol 121
Pages: 769-770
Peer Reviewed
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[Journal Article] Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population, family and case-control study2008
Author(s)
Enomoto H, Hirata K, Otsuka K, Kawai T, Takahashi T, Hirota T, Suzuki Y, Tamari M, Otsuka F, Fujieda S, Arinami T, Noguchi E.
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Journal Title
J Hum Genet 57
Pages: 615-621
Peer Reviewed
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