2010 Fiscal Year Final Research Report
Analysis for carcinogenesis of lung cancer in idiopathic pulmonary fibrosis by inflammation and precancerous change
| Project/Area Number |
20590336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OTA Satoshi The University of Tokyo, 大学院・医学系研究科, 講師 (90324342)
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| Co-Investigator(Kenkyū-buntansha) |
FUKAYAMA Masashi 東京大学, 大学院・医学系研究科, 教授 (70281293)
ISHIKAWA Shunpei 東京大学, 大学院・医学系研究科, 准教授 (50418638)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺がん |
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| Research Abstract |
Idiopathic pulmonary fibrosis is the interstitial pneumonia of unknown cause and refractory lesion, with a high risk for lung cancer. To study the difference of squamous cell carcinoma with or without idiopathic pulmonary fibrosis, the transcriptome expression level of each squamous cell carcinoma sample were compared. Famous oncogene MYCN, cytoskeleton protein MYH11, unknown function protein ARMC4 were upregulated. One of downregulated protein was MTSS-1 which supposed to be the role as disassembling the actin fibers.
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