2010 Fiscal Year Final Research Report
Pathological examination about the effects of angiogenic factors on the exacerbation and the improvement of vascular lesions
| Project/Area Number |
20590342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKANO Toshiaki Kyushu University, 大学病院, 助教 (10432931)
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| Co-Investigator(Kenkyū-buntansha) |
SUEISHI Katsuo 九州大学, 医学研究院, 教授 (70108710)
TSURUYA Kazuhiko 九州大学, 医学研究院, 客員教授 (20372740)
MASUTANI Kosuke 九州大学, 大学病院, 助教 (30419593)
TANIGUCHI Masatomo 九州大学, 医学研究院, 助教 (60419562)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血管新生 / 動脈硬化 |
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| Research Abstract |
Atherosclerotic diseases are a significant public health problem to prevent. Atherosclerosis is associated with an increased risk of death, especially in coronary heart disease and chronic kidney disease (CKD). We investigated the mechanisms of atherosclerosis proceeded with the focus on angiogenic factors. We revealed that VEGF-A and VEGF-C progressed atherosclerotic lesions of ApoE-KO mice. We also revealed that CKD was associated with an increased risk of coronary heart disease caused by the acceleration of chronic inflammation.
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