2010 Fiscal Year Final Research Report
Establish of anti-liver metastasis therapy of colorectal cancer-targeting of angiotensin activation system
| Project/Area Number |
20590349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nara Medical University |
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Principal Investigator |
KUNIYASU Hiroki Nara Medical University, 医学部, 教授 (00253055)
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| Co-Investigator(Renkei-kenkyūsha) |
DENDA Ayumi 奈良県立医科大学, 医学部, 講師 (90110858)
SASAHIRA Tomonori 奈良県立医科大学, 医学部, 助教 (90405374)
OOMORI Hitoshi 奈良県立医科大学, 医学部, 博士研究員 (80213875)
HUJII Kiyomu 奈良県立医科大学, 医学部, 博士研究員 (60284189)
BHAWAL Ujjal 奈良県立医科大学, 医学部, 博士研究員 (50433339)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 消化器 / 唾液腺 |
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| Research Abstract |
Angiotensin provides pro-tumoral effects. Our study reveals colorectal cancer cells possess the hyperglycemia-induced angiotensin-activating mechanism, which is associated with liver metastasis. These findings suggest a new molecular target for liver metastasis of colorectal cancer. MAS1 is a receptor of angiotensin 1-7, which is a degradation product of angiotensin I and II. MAS1 expression is decreased in breast ductal carcinomas, especially in scirrhous carcinomas. MAS1 levels are reversely correlated with stage, nodal metastasis, and HER2 expression. These findings suggest that MAS1 might be a novel tumor suppressor gene in breast cancer.
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[Journal Article] High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma.2008
Author(s)
Sasahira T, Kirita T, Oue N, Bhawal UK, Yamamoto K, Fujii K, Ohmori H, Luo Y, Yasui W, Bosserhoff AK, Kuniyasu H
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Journal Title
Cancer Sci 99(9)
Pages: 1806-1812
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[Journal Article] Basic helix-loop-helix transcription factor DEC1 negatively regulates CyclinD1.
Author(s)
Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kajima H, Kuniyasu H, Abiko Y, Kato Y, Sato S
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Journal Title
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[Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingival inflammation.
Author(s)
Ito Y, Bhawal UK, Sasahira T, Toyama T, Sato T, Matsuda D, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H
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