2010 Fiscal Year Final Research Report
Molecular mechanisms maintaining leukemic stem cells by forkhead transcription factor Foxo
| Project/Area Number |
20590394
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
NAKA Kazuhito Kanazawa University, がん研究所, 准教授 (70372688)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | がん幹細胞 / 慢性骨髄性白血病 / 抗がん剤抵抗性 / FOXO / TGF-・阻害剤 |
|---|
| Research Abstract |
In this study, we demonstrated a critical role for the TGF-β-FOXO pathway in maintenance and imatinib resistance of leukemia-initiating cells (LICs) in chronic myeloid leukemia (CML) which are responsible for recurrence of disease. TGF-β inhibitor in combination with imatinib treatment led to efficient depletion of LICs in vivo.
|
-
[Journal Article] Suppression of glioma-initiating cell self-renewal by NKX2.2.2011
Author(s)
Muraguchi T., Tanaka S., Yamada D., Tamase A., Nakada M., Nakamura H., Hoshii T., Ooshio T., Tadokoro Y., Naka K., Ino Y., Todo T., Kuratsu J., Saya H., Hamada J., Hirao A.
-
Journal Title
Cancer Res. 71(3)
Pages: 1135-1145
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
