2010 Fiscal Year Final Research Report
Regulation of IL12 production in the induction of protective immune response against Leishmania infection
| Project/Area Number |
20590424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
HONMA Kiri Nagasaki University, 大学院・医歯薬学総合研究科, 講師 (70307940)
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| Co-Investigator(Kenkyū-buntansha) |
YUI Katsuyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90274638)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リーシュマニア / IRF4 / マクロファージ / 樹状細胞 |
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| Research Abstract |
Reduction of footpad swelling in IRF4 KO after Leishmania infection compared to resistant mice revealed to be due to defect of IRF4 in dendritic cells not macrophages by the experiments using conditional KO. Unlike splenic DC, CD4+ DC subset was observed in lymph node in IRF4 KO. It suggested that DC differentiation in LN was different from that in spleen. Recruitment of CD103+ DC, which was a kind of skin DC, in IRF4 KO was slower than WT within 48 hrs after infection.
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Research Products
(15 results)
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[Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.2010
Author(s)
Satoh T., Takeuchi O., Vandenbon A., Yasuda K., Tanaka Y., Kumagai Y., Miyake I., Matsushita K., Okazaki T., Saitoh T., Honma K., Matsuyama T., Yui K., Tsujimura T., Standley D., Nakanishi K., Nakai K., Akira S.
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Journal Title
Nat.Immunol. 11
Pages: 936-944
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[Remarks] ホームページ等
