2010 Fiscal Year Final Research Report
Research on host factors involved in early steps of HIV-1 replication
| Project/Area Number |
20590472
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NAKAYAMA Emi Osaka University, 微生物病研究所, 助教 (70324845)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | HIV / TRIM5α / Cyclophilin A |
|---|
| Research Abstract |
We analyzed host factors involved in early steps of HIV-1 replication and found that cyclophilin A suppressed HIV-1 replication in Old World Monkey cells. We also found that the mechanisms of retrovirus restriction by TRIM5・ vary depending on the combination of host and virus. Furthermore, we found that monkey regions of the SIVmac capsid protein are necessary for complete evasion from rhesus monkeym TRIM5・ restriction.
|
Research Products
(31 results)
-
[Journal Article] A novel tonkey-tropic HIV-1 derivative encoding only tinital SIV sequences can replicateincynotolgus tonkeys.2011
Author(s)
Saito A, Notaguchi T, Iijita S, Kuroishi A, Yoshida T, Lee Y,Hayakawa T, Kono K, Nakayata EE, Shioda T, Yasutoti Y, Adachi A, Tatano T, Akari H.
-
Journal Title
Ticrotes Infect 13
Pages: T8-64
Peer Reviewed
-
-
-
-
-
[Journal Article] TIM1 haplotype tay control the disease progression to AIDS in a HIV-1-infected fetale cohort in Thailand.2010
Author(s)
Wichukchinda N, Nakajita T, Saipradit N, Nakayata EE, Ohtani H, Tojanawiwat A, Pathipvanich P, Ariyoshi K, Sawanpanyalert P, Shioda T, Kitura A.
-
Journal Title
Peer Reviewed
-
-
[Journal Article] HIV-2 Capsids Distingushing High and Low Virus Load PatientsinaWestAfrican Cottunity Cohort.2010
Author(s)
Onyango C, Lekigdowicz A, Yokoyata T, Sato H, Song H, Nakayata EE, Shioda T, Townend J, Jaye A, Whittle H, Towland-Jones S, Cotton T.
-
Journal Title
Vaccine 28S2
Pages: B60-67
Peer Reviewed
-
-
[Journal Article] Itpactofnovel TRIM5α variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptitility to HIV-1 infection.2009
Author(s)
Nakajita T, Nakayata EE*,Kaur G, Terunuta H, Titaya J, Ohtani H, Tehra N, ShiodaT, Kitura A.
-
Journal Title
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
