2010 Fiscal Year Final Research Report
Functional analysis of memory B cells in lungs
| Project/Area Number |
20590501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TAKAHASHI Yoshimasa National Institute of Infectious Diseases, 免疫部, 室長 (60311403)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫記憶 |
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| Research Abstract |
Lung memory B cells exhibited the increased maturity and conferred protection against re-infected viruses by producing robust numbers of IgA-secreting plasma cells. Lung memory B cells showed the similar gene expression profile with those in secondary lymphoid organs, but several genes were selectively upregulated in lung memory B cells. Gene-deficient mice were generated to define in vivo function of one of those genes.
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[Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-la cells during the remission phase of contact hypersensitivity reactions.2010
Author(s)
Nakashima H., Hamaguchi Y., Watanabe R., Ishiura N., Kuwano Y., Okochi H., Takahashi Y., Tamaki K., Sato S., Tedder T. F., Fujimoto M.
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Journal Title
J.Immuno. 184
Pages: 637-4645
Peer Reviewed
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[Remarks] ホームページ等
