2010 Fiscal Year Final Research Report
The usefulness of chemotherapy with S-1 for Japanese patients with non-small-cell lung cancer based on CYP2A6*4 gene polymorphism
Project/Area Number |
20590536
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
INUI Naoki Hamamatsu University School of Medicine, 医学部・臨床薬理学, 助教 (80402254)
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Co-Investigator(Kenkyū-buntansha) |
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
CHIDA Kingo 浜松医科大学, 医学部, 准教授 (40197611)
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Project Period (FY) |
2008 – 2010
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Keywords | 薬物治療学 / 薬物代謝酵素 / 個別化治療 / 抗癌剤S-1 / 肺癌 |
Research Abstract |
The frequencies of the CYP2A6^*4C was 17.4%. In the S-1 pharmacokinetic analysis, the area under the concentration-time curve from 0 to 10 hours (AUC) ratios of 5-FU/tegafur showed large interindividual variabilities, ranging from 5.14 to 112.6. The AUC for tegafur was 1.5-fold higher in patients with the CYP2A6^*4C allele than in patients without the CYP2A6^*4C allele. Patients with the CYP2A6^*4C allele had a significantly lower maximum plasma concentration for 5-FU than patients without the CYP2A6^*4C allele.
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Research Products
(8 results)
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[Journal Article] Phase II study of combination chemotherapy with S-1 and weekly cisplatin in patients with previously untreated advanced non-small cell lung cancer.2009
Author(s)
Ozawa Y, Inui N, Naitoh T, Yasuda K, Nagayama M, Shirai T, Suganuma H, Fujii M, Nakamura H, Suda T, Chida K.
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Journal Title
Lung Cancer. 63
Pages: 68-71
Peer Reviewed
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