A case-control study of breast cancer in relation to the risk for estrogen levels in breast tissue and in situ estrogen production

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590630
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Tohoku University
• Principal Investigator: MINAMI Yuko Tohoku University, 大学院・医学系研究科, 教授 (60239316)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629) ; KAKUGAWA Yoichiro 宮城県立がんセンター(研究所), 生化学部, 特任研究員 (60221173)
• Co-Investigator(Renkei-kenkyūsha): OHUCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710) ; TATENO Hiroo 宮城県立がんセンター(研究所), 病理学部, 部長 (70004744) ; TADA Hiroshi 宮城県立がんセンター(研究所), 薬物療法学部, 特任研究員 (50436127)
• Project Period (FY): 2008 – 2010
• Keywords: 乳がん / エストロゲン / ホルモンレセプター / 乳腺組織 / 授乳

Research Abstract

We investigated the associations between hormone levels in blood and in breast cancer tissue and risk factors of breast cancer using data from 62 postmenopausal breast cancer patients. Estradiol (E2) level in tissue was 43.7 times compared with that in blood among patients with ER+ or PR+ breast cancer, whereas 14.5 times among patients with ER-/PR-. In addition, E2 level in receptor positive breast cancer tissue tended to be higher among breast cancer patients with history of breast feeding. There is a possibility that E2 is produced in breast tissue or taken from blood. History of breast feeding may be related to the mechanisms responsible for the accumulation of E2 in breast tissue.

Research Products

• [Journal Article] Alcohol consumption and breast cancer risk in Japanese women : The Miyagi Cohort Study (2011)
  • Author(s): kawai M, Minami Y, Kakizaki M, Kakugawa Y, Nishino Y, Fukao A, Tsuji I, Ohuchi N
  • Journal Title: Breast Cancer Res Treat [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Breast cancer aromatase expression evaluated by the novel antibody 677 : Correlations to intra-tumor estrogen levels and hormone receptor status (2010)
  • Author(s): Geisler J, Suzuki T, 他9名
  • Journal Title: J Steroid Biochem Mol Biol 118 Pages: 237-241
  • Peer Reviewed
• [Journal Article] Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women : the Miyagi cohort Study (2010)
  • Author(s): Kawai M, Minami Y, Kuriyama S, Kakizaki M, Kakugawa Y, Nishino Y, Ishida T, Fukao A, Tsuji I, Ohuchi N
  • Journal Title: Br J Cancer 103 Pages: 1443-1447
  • Peer Reviewed
• [Journal Article] Reproductive factors, exogenous female hormone use and breast cancer risk in Japanese : the Miyagi Cohort Study (2010)
  • Author(s): Kawai M, Minami Y, Kuriyama S, Kakizaki M, Kakugawa Y, Nishino Y, Ishida T, Fukao A, Tsuji I, Ohuchi N
  • Journal Title: Cancer Causes Control 21 Pages: 135-145
  • Peer Reviewed
• [Journal Article] Intracrinology of sex steroids in ductal carcinoma in situ (DCIS) of human breast : comparison to invasive ductal carcinoma (IDC) and non-neoplastic breast (2009)
  • Author(s): Miki Y, Suzuki T, Sasano H
  • Journal Title: J Steroid Biochem Mol Biol 114 Pages: 68-71
  • Peer Reviewed
• [Journal Article] 17b-hydroxysteroid dehydrogenase type 12 in human breast carcinoma : a prognostic factor via potential regulation of fatty acids synthesis (2009)
  • Author(s): Nagasaki S, Suzuki T, Miki Y, Akahira J, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H
  • Journal Title: Cancer Res 69 Pages: 1392-1399
  • Peer Reviewed
• [Presentation] 日本人女性における成人期の肥満、体重変化と乳がんリスクの関連 (2010)
  • Author(s): 河合賢朗、南優子
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 初発時血清ホルモン値と乳癌予後との関連 (2010)
  • Author(s): 角川陽一郎、南優子
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25
• [Presentation] 女性ホルモン剤使用と乳癌罹患に関するコホート研究 (2009)
  • Author(s): 河合賢朗、南優子
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-03
• [Remarks] ホームページ等