The roles of unsaturated fatty acids in breast cancer risk and the responsiveness to treatment

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590650
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kagoshima University
• Principal Investigator: KORIYAMA Chihaya Kagoshima University, 医歯学総合研究科, 准教授 (30274814)
• Co-Investigator(Kenkyū-buntansha): AKIBA Suminori 鹿児島大学, 医歯学総合研究科, 教授 (50145554) ; KIJIMA Yuko 鹿児島大学, 医学部・歯学部附属病院, 助教 (60381175) ; SHINGUJI MEGUMI 鹿児島大学, 医歯学総合研究科, 助教 (70418862)
• Project Period (FY): 2008 – 2010
• Keywords: 乳がん / 不飽和脂肪酸 / 治療感受性

Research Abstract

In the present study, the association between n-3 highly-unsaturated fatty acids in serum and the breast cancer risk was examined in taking account the risk factors of breast cancer such as age, obesity, reproductive history and other life styles. There was no significant difference in the ratios of arachidonic acid to EPA and DHA in blood serum between breast cancer case and control groups. There was a weakly-positive association between the ratio of arachidonic acid to DHA and depressive state in breast cancer patients.

Research Products

• [Journal Article] Determination and characterization of hydroxylated polychlorinated biphenyls (OH-PCBs) in serum and adipose tissue of Japanese women diagnosed with breast cancer. (2010)
  • Author(s): Nomiyama K, Yonehara T, Yonemura S, Yamamoto M, Koriyama C, Akiba S, Shinohara R, Koga M.
  • Journal Title: Environmental Science and Technology 44(8) Pages: 2890-2896
  • Peer Reviewed
• [Presentation] Prognostic role of HPV in adenocarcinomas of the breast and the lung. (2010)
  • Author(s): Koriyama C, Kijima Y, Yanagi M, Khan N, Yoshinaka H, Natsugoe S, Eizuru Y, Akiba S.
  • Organizer: 69^<th> Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Osaka (Osaka)
  • Year and Date: 20100922-20100924
• [Presentation] Residual organochlorine levels in breast adipose tissue among Japanese women with breast cancer and benign tumor of the breast. (2008)
  • Author(s): Koriyama C, Shinkura R, Ando T, Yamamoto M, Koga M, Ryota S, Arizono K, Tsuji M, Sagara Y, Akiba S.
  • Organizer: The second JCA-AACR Special Joint Conference.
  • Place of Presentation: Awaji (Hyogo)
  • Year and Date: 20080714-20080716