2010 Fiscal Year Final Research Report
Development of therapeutics for dementia targeting Abeta clearance
| Project/Area Number |
20590697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Naoyuki Osaka University, 大学院・医学系研究科, 寄付講座准教授 (70372612)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルツハイマー病 / ベータ / アミロイド |
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| Research Abstract |
We found that statin reduced Abeta level in mouse brain and identify its mechanism. Statin inhibited Abeta production and up-regulated Abeta clearance. Up-regulation of Abeta clearance seemed likely to be mediated by the increase of LRP-1 expression. Inhibition of protein isoprenylation is involved in both inhibition of Abeta production and up-regulation of Abeta clearance.
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Research Products
(23 results)
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[Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance.2010
Author(s)
Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
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Journal Title
The Journal of Biological Chemistry 285
Pages: 22091-102
Peer Reviewed
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[Journal Article] Prevention of dementia by antihypertensive drugs : how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients and ACE-inhibitors.2009
Author(s)
Fournier A, Oprisiu-Fournier R, Serot JM, Godefroy O, Achard JM, Faure S, Mazouz H, Temmar M, Albu A, Bordet R, Hanon O, Gueyffier F, Wang J, Black S, Sato N.
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Journal Title
Expert Rev Neurother 9(9)
Pages: 1413-31
Peer Reviewed
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