2010 Fiscal Year Final Research Report
Roles of endocannabinoid in the modulation of central sympatho-adrenomedullary outflow in rat
| Project/Area Number |
20590702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
YOKOTANI Kunihiko Kochi University, 教育研究部・医療学系, 教授 (30174858)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takahiro 高知大学, 教育研究部・医療学系, 助教 (00363276)
TANAKA Kenjirou 高知大学, 教育研究部・医療学系, 助教 (30552260)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 交感神経-副腎髄質系の中枢性賦活 / アラキドン酸カスケード / ホスホリパーゼC / ジアシルグリセロールリパーゼ / 2-アラキドノイルグリセロール / エンドカンナビノイド |
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| Research Abstract |
We tried to clarify the role of monoacylglycerol (MAG) involved in the central activation of sympatho-adrenomedullary (S-A) outflow by intracerebroventricular administration of stress-related peptides (CRF, vasopressin, bombesin) using anesthetized rats. Elevation of plasma catecholamines evoked by these peptides is mediated by arachidonic acid cascade produced by phospholipase C/diacylglycerol lipase/MAG lipase-mediated mechanisms. In addition, MAG (=2-arachidonoylglycerol: the most powerful endocannabinoid) reduced these peptide-induced activation of S-A outflow through CB1 receptor-mediated mechanisms in rats.
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Research Products
(19 results)
