2010 Fiscal Year Final Research Report
Research on the mechanism of alcohol-related carcinogenesis and itsapplication for prevention and early detection in clinical
| Project/Area Number |
20590720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
MUTO Manabu Kyoto University, 医学研究科, 准教授 (40360698)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルコール関連発癌 / ALDH2 / 予防 / DNAアダクト / 呼気テスト |
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| Research Abstract |
While alcohol drinking has been considered as carcinogen to the esophageal cancer as well as smoking, definite mechanism has been unclear.
We revealed that difference in activities of alcohol metabolizing enzymes could affect the tendency of DNA damage in the esophagus after drinking. And half-life of the DNA damage was around 35 hours. Then, chronic alcohol exposure has a potential of carcinogenic effect in the esophagus. Carcinogens in the breath after drinking might in part play an important role in the alcohol-related carcinogenesis in the esophagus.
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[Journal Article] Artificially induced epithelail mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research.2011
Author(s)
Aoyagi K, Minashi K, Igaki H, Tachimori Y, Nisimura T, Hokamura N, Ashida A, Daiko H, Ochiai A, Muto M, Ohtsu A, Yoshida T, Sasaki H.
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Journal Title
PLos ONE. 6(4)
Pages: e18196
Peer Reviewed
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[Journal Article] Submucosal tumor appearance is a useful endoscopic predictor of early primary-site recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma.2010
Author(s)
Tu CH, Muto M, Horimatsu T, Taku K, Yano T, Minashi K, Onozawa M, Nihei K, Ishikura S, Ohtsu A, Yoshida S.
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Journal Title
Peer Reviewed
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[Journal Article] Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial.2010
Author(s)
Muto M, Minashi K, Yano T, Saito Y, Oda I, Nonaka S, Omori T, Sugiura H, Goda K, Kaise M, Inoue H, Ishikawa H, Ochiai A, Shimoda T, Watanabe H, Tajiri H, Saito D.
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Journal Title
J Clin Oncol 28(9)
Pages: 1566-1572
Peer Reviewed
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[Journal Article] Narrow band imaging for detecting superficial squamous cell carcinoma of the head neck in patients with esophageal squmaous cell carcinoma.2010
Author(s)
Katada C, tanabe S, Koizumi W, Higuchi K, Tohru Sasaki, Azuma M, Katada N, Masaki T, Nakayama M, Okamoto M, Muto M.
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Journal Title
Endoscopy 42(3)
Pages: 185-190
Peer Reviewed
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[Journal Article] Relationship between MVD and meshed-capillaries using magnifying NBI colonoscopy in colorectal precursor lesions.2009
Author(s)
Horimatsu T, Sano Y, Kaneko K, Ikematsu H, Katagiri A, Yano T, Fu KI, Muto M, Fujii S, Ochiai A, Yoshida S.
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Journal Title
Hepatogastroenterology. 56(90)
Pages: 372-7
Peer Reviewed
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[Journal Article] Expression of cytochrome P450 in non-small cell lung cancer.2008
Author(s)
Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Urammoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T.
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Journal Title
Frontiers in Bioscience 13
Pages: 5787-5793
Peer Reviewed
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[Journal Article] Long-term outcome of trans-oral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer.
Author(s)
Muto M, Satake H, Yano T, Minashi K, Hayashi R, Fujii S, Ochiai A, Ohtsu A, Morita h, Horimatsu T, Ezoe Y, Miyamoto S, Asato R, Tateya I, Yoshizawa A, Chiba T.
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Journal Title
Gastrointest Endosc in press
Peer Reviewed
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