2010 Fiscal Year Final Research Report
Role of REG protein in the regeneration and carcinogenesis of colorectal epithelial cells
| Project/Area Number |
20590747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
FUKUI Hirokazu Dokkyo Medical University, 医学部, 講師 (60378742)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子 / 癌 / 再生医学 / 病理学 / 臨床 |
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| Research Abstract |
REG protein is induced by Interleukins 6 and 22 stimulations in colitis tissues. REG protein has an anti-apoptotic effect on colonic epithelial cells and its effect may play a role in the development of inflammation-related cancers. REG protein is overexpressed in the dysplastic lesion in ulcerative colitis tissues, and therefore, its detection may be an useful tool to not only diagnose but also predict ulcerative colitis-related neoplastic lesions.
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[Journal Article] Immunohistochemical analysis of REG I expression in ulcerative colitis-associated neoplastic lesions.2011
Author(s)
Tanaka H, Fukui H, Fujii S, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Yasuda Y, Chiba T, Fujimori T
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Journal Title
Digestion 83
Pages: 204-209
Peer Reviewed
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[Journal Article] Involvement of the IL-22/REG I axis in ulcerative colitis.2010
Author(s)
Sekikawa A, Fukui H, Suzuki K, Karibe T,Fujii S, Ichikawa K, Tomita S, Imura J, Shiratori K, Chiba T, Fujimori T
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Journal Title
Lab Invest 90
Pages: 496-505
Peer Reviewed
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