2010 Fiscal Year Final Research Report
Research on voltage-gated Kv1,3 K^+ channel for the pathogenesis of autoimmune pancreatitis
| Project/Area Number |
20590805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shinshu University |
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Principal Investigator |
KAWA Shigeyuki Shinshu University, 総合健康安全センター, 教授 (10177628)
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| Co-Investigator(Kenkyū-buntansha) |
OTA Masao 信州大学, 医学部, 准教授 (50115333)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 自己免疫性膵炎 / カリウムイオンチャンネル蛋白 / Kv1,3 / ゲノムワイド解析 |
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| Research Abstract |
To identify genetic factors that might contribute to autoimmune pancreatitis, we identified the voltage-gated Kv1.3 channel protein regulated by KCNA3. We investigated its role in the pathogenesis, but found no significant association. Using genome wide association study, we found 25 candidate genes on 14 chromosomes, which are associated with susceptibility to autoimmune pancreatitis. We are confirming the association by fine mapping with SNPs within these genes.
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