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2010 Fiscal Year Final Research Report

Development of new treatment for atherosclerosis by regulating cell-mediated immunity

Research Project

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Project/Area Number 20590880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISOBE Mitsuaki  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80176263)

Co-Investigator(Kenkyū-buntansha) SUZUKI Juniichi  東京医科歯科大学 (90313858)
Project Period (FY) 2008 – 2010
Keywords動脈硬化 / 心臓移植 / 冠動脈再狭窄 / 細胞性免疫 / トランスジェニックマウス
Research Abstract

We investigated the role of cell-mediated immunity on the mechanism of arterioscelrosis using mouse models of cardiac allograft transplantation and wire-induced injury of the femoral artery. We paid attention to MMP-9, ICAM-1, and adiponectin as mediators or suppressors of arteriosclerosis in these models. Clarithromycin which suppresses MMP-9 activity and siRNA ICAM-1 were effective in suppressing arterial lesions and adiponectin over expression mouse showed lesser extent of chronic allograft rejection. These results indicate the role of immunity and inflammation on the arterioscelrosis and these new agents may be useful as new targets for prevention of clinical diseases.

  • Research Products

    (17 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results)

  • [Journal Article] The effects of pharmacological plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts.2011

    • Author(s)
      Ogawa M, Suzuki J, Yamaguchi Y, Muto S, Itai A, Hirata Y, Isobe M, Nagai R.
    • Journal Title

      Transplantation. 91(1)

      Pages: 21-26

  • [Journal Article] Ultrasound-Microbubble Mediated ICAM-1 siRNA Transfection Attenuates Neointimal Formation after Arterial Injury in Mice.2010

    • Author(s)
      Suzuki J, Ogawa M, Takayama K, Taniyama Y, Morishita R, Hirata Y, Nagai R, Isobe M
    • Journal Title

      J Am Coll Cardiol 55

      Pages: 904-913

  • [Journal Article] Inhibition of endostatin deterioratesleft ventricular remodeling and heart failure through matrix proteinases and angiotensin converting enzyme in rat myocardial infarction.2010

    • Author(s)
      Isobe K, Kuba K, Maejima Y, Suzuki J, Kubota S, Isobe M
    • Journal Title

      Circ J 74(1)

      Pages: 109-119

  • [Journal Article] Treatment with telmisartan attenuates graft arterioscelrosis in murine cardiac allografts.2010

    • Author(s)
      Kosuge H, Ishihara T, Haraguchi G, Maejima Y, Okada H, Saiki H, Suzuki H, Isobe M
    • Journal Title

      J Heart Lung Transplant 29(Jan)

      Pages: 562-567

  • [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010

    • Author(s)
      Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia C-p, Keene AC, Alayari NN, Elling U, Berger C, Novatchkova M, Koglgruber R, Nishina H, Isobe M, Pospisilik JA, Imai Y, Knoblich JA, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Bodmer R, Penninger JM
    • Journal Title

      Cell 41

      Pages: 1-12

  • [Journal Article] Matrix metalloproteinase suppression induced by clarithromycin in murine cardiac allografts.2009

    • Author(s)
      Ogawa M, Suzuki J, Takayama K, Isobe M.
    • Journal Title

      Transplant Proc. 41

      Pages: 395-397

  • [Journal Article] An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention.2009

    • Author(s)
      Suzuki J, Tezuka D, Morishita R, Isobe M
    • Journal Title

      J Gene Med 11

      Pages: 89-91

  • [Journal Article] The Mechanism of Anti-Inflammatory Effects of Prostaglandin E2 Receptor 4 Activation in Murine Cardiac Transplantation.2009

    • Author(s)
      Ogawa M, Suzuki J, Isobe M
    • Journal Title

      Transplantation 87

      Pages: 1645-1653

  • [Journal Article] A critical role of COX-2 in the progression of neointimal formation after wire injury in mice.2009

    • Author(s)
      Ogawa M, Suzuki J, Hirata Y, Nagai R, Isobe M.
    • Journal Title

      Expert Opin Ther Targets. 13

      Pages: 505-511

  • [Journal Article] Clarithromycin Attenuates Acute and Chronic Rejection via MMP Suppression in Murine Cardiac Transplantation.2008

    • Author(s)
      Ogawa M, Suzuki J, Isobe M
    • Journal Title

      J Am Coll Cardiol 51

      Pages: 1977-1985

  • [Journal Article] Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts.2008

    • Author(s)
      Saiki H, Suzuki J, Kosuge H, Haraguchi G, Ishihara T, Haga T, Maejima Y, Isobe M, Uede T
    • Journal Title

      Int Heart J 49

      Pages: 105-118

  • [Journal Article] Long-term follow up of initial clinical cases with NF-kB decoy oligodeoxynucleotide transfecton at the site of coronary stenting.2008

    • Author(s)
      Egashira K, Suzuki J, Ito H, Aoki M, Isobe M, Morishita R
    • Journal Title

      J Gene Med 10

      Pages: 805-809

  • [Journal Article] The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury.2008

    • Author(s)
      Suzuki J, Ogawa M, Muto S, Yamaguchi Y, Itai A, Isobe M
    • Journal Title

      Expert Opin Ther Targets 12

      Pages: 783-794

  • [Journal Article] Suppression of neointimal hyperplasia after vascular injury by blocking 4-1BB/4-1BB ligand pathway.2008

    • Author(s)
      Karube A, Suzuki J, Haraguchi G, Maejima Y, Saiki H, Kosuge H, Isobe M, Uede T
    • Journal Title

      J Med Dent Sci 55

      Pages: 207-213

  • [Journal Article] Adioponectin protects doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK upregulation in mice.

    • Author(s)
      Konishi M, Haraguchi G, Ishihara T, Ohgashi H, Saito K, Nakano Y, Isobe M
    • Journal Title

      Cardiovasc Res in press

  • [Journal Article] Porphyromonas gingivalis Promotes Murine Abdominal Aortic Aneurysms via Matrix Metalloproteinase-2 Induction.

    • Author(s)
      Aoyama N, J Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M
    • Journal Title

      J Period Res in press

  • [Journal Article] The effect of adiponectin on the cardiac allograft vasculopathy.

    • Author(s)
      Ishihara T, Haraguchi G, Konishi M, Ohigashi H, Saito K, Nakano Y, Isobe M
    • Journal Title

      Circ J in press

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Published: 2012-01-26   Modified: 2016-04-21  

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