2010 Fiscal Year Final Research Report
The effect of aging and smoking on the phagocytosis of apoptotic cells in alveolar macrophages
| Project/Area Number |
20590890
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
NASUHARA Yasuyuki Hokkaido University, 病院, 准教授 (30322811)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yoko 北海道大学, 病院, 助教 (90286451)
BETSUYAKU Tomoko 北海道大学, 大学院・医学研究科, 准教授 (60333605)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 閉塞性肺疾患 / マクロファージ / 喫煙 / アポトーシス / 炎症 |
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| Research Abstract |
Our aims of this study are to examine expressions of various receptors for recognition and/or clearance of apoptotic cells on macrophages and assess the relationship with aging and/or smoking. The expression of phosphatidylserine receptor (PSR) and scavenger receptor A (SR-A) in alveolar macrophages was downregulated in smokers when compared to lifelong non-smokers only in the older subjects, but not in younger subjects. The expression of PSR is elevated on U937-derived macrophage like cells if these are incubated in CSE. The cigarette smoke extract-induced upregulation of PSR was inhibited by the vascular endothelial growth factor (VEGF) receptor blockade, SU5614, in U937-derived macrophage-like cells. These results showed that VEGF was indirectly associated with the ability to phagocytose apoptotic cells through the expression of PSR.
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Research Products
(47 results)
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[Journal Article] The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema.2011
Author(s)
Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM.
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Journal Title
Am J Respir Crit Care Med. 183
Pages: 876-884
Peer Reviewed
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[Journal Article] Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts.2010
Author(s)
Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA.
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Journal Title
Am J Respir Cell Mol Biol. 43
Pages: 576-584
Peer Reviewed
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[Journal Article] Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients2008
Author(s)
Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M.
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Journal Title
Inhal Toxicol 20(3)
Pages: 349-3
Peer Reviewed
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[Presentation] Duration of cigarette smoke (CS) exposure affects the resolution of lung inflammation after cessation in mice.2009
Author(s)
Odajima N, Betsuyaku T, Inomata T, Yoshida T, Moriyama C, Suzuki K, Nagai K, Nasuhara Y, Nishimura M
Place of Presentation
The San Diego Convention Center, San Diego, CA, United States.
Year and Date
2009-05-17
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