2010 Fiscal Year Final Research Report
A role of insulin signal impairment in the pathogenesis of Alzheimer disease
| Project/Area Number |
20590990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
IKEUCHI Takeshi Niigata University, 脳研究所, 助教 (20372469)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルツハイマー病 / 認知症 / 糖尿病 / インスリンシグナル伝達 |
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| Research Abstract |
Insulin resistance caused by diabetes is now recognized as risk factor of Alzheimer disease (AD). We conducted a research to verify a role of insulin signal impairment in AD pathogenesis and here provide following findings. i) increase of insulin in culture medium leads to enhanced production of β-amyloid (Aβ). ii) overproduction of Aβ induces abnormal phosphorylation of tau, iii) insulin signal transduction is impaired by overproduction of Aβ. These findings suggest that heperinsulinemia may accelerates AD pathogenesis and insulin signal transduction may play a role in Aβ-induced tau phosphorylation.
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[Journal Article] Dementia Geriat Cogn Disord2010
Author(s)
Ikeuchi T, Hirayama S, Miida T, Fukamachi I, Tokutake T, Ebinuma H, Takubo K, Kaneko H, Kasuga K, Kakita A, Takahashi H, Bujo H, Saito Y, Nishizawa M.
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Journal Title
Peer Reviewed
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[Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, parkinsonism and motor neuron disease : a distinct clinicopathological and biochemical disease entity.2010
Author(s)
Fu Y, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koide R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H.
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Journal Title
Acta Neuropathologica 120
Pages: 21-32
Peer Reviewed
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[Journal Article] Differential levels of α-synuclein, β-amyloid, and tau in cerebrospinal fluid between patients with dementia with Lewy bodies and Alzheimer disease.2010
Author(s)
Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O, Nishizawa M, Ikeuchi T.
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Journal Title
Journal of Neurology, Neurosurgery & Psychiatry 81
Pages: 608-610
Peer Reviewed
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[Journal Article] Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease.2009
Author(s)
Kasuga K, Shimohata T, Nishimura A, Shiga A, Mizuguchi T, Tokunaga J, Ohno T, Miyashita A, Kuwano R, Matsumoto N, Onodera O, Nishizawa M, Ikeuchi T.
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Journal Title
Journal of Neurology, Neurosurgery & Psychiatry 80
Pages: 1050-1052
Peer Reviewed
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[Journal Article] The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system.2009
Author(s)
Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S,T Arai T, Ikeuchi T, Kasuga K, Tokuda T, Masaki Kondo M, Masaki Ikeda M, Kentaro Deguchi K, Hiroaki Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
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Journal Title
EMBO Molecular Medicine 1
Pages: 223-235
Peer Reviewed
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[Presentation] アルツハイマー病患者・髄液中では可溶性LR11が増加する2010
Author(s)
池内健, 平山哲, 三井田孝, 深町勇, 矢島隆二, 徳武孝允, 春日健作, 金子博之, 田久保耕平, 海老沼宏幸, 武城英明, 西澤正豊
Organizer
第29回日本認知症学会学術集会
Place of Presentation
名古屋
Year and Date
2010-11-05
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[Remarks] ホームページ等
