Development of therapy and identification of new tumor suppressor genes in childhood acute Lymphoblastic leukemia

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kochi University
• Principal Investigator: TAKEUCHI Seisho Kochi University, 教育研究部・医療学系, 准教授 (50253349)
• Project Period (FY): 2008 – 2010
• Keywords: 血液腫瘍学 / 小児急性リンパ性白血病 / 異常メチル化 / 癌抑制遺伝子

Research Abstract

Methylation profile was analyzed in patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age. Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precursor B-ALL. In contrast, methylation of the DAPK gene was more frequent in precursor B-ALL. Patients with methylation of multiple genes more likely had T cell phenotype, and are classified as medium/high risk. These results suggest that methylation status is associated with clinicopathological features in childhood ALL.

Research Products

• [Journal Article] MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells. (2008)
  • Author(s): Nishioka C, Ikezoe T, Yang J, Takeuchi S, Koeffler HP, Yokoyama A
  • Journal Title: Leukemia Ressearch 32 Pages: 1382-1392
  • Peer Reviewed
• [Journal Article] Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia.
  • Author(s): Takeuchi S, Matsushita M, Zimmermann M, Ikezoe T, Komatsu N, Seriu T, Schrappe M, Bartram CR, Koeffler HP
  • Journal Title: Leukemia Research in press
  • Peer Reviewed
• [Journal Article] Aberrant methylation in promoter-associated CpG islands of multiple genes in blast crisis of chronic myelogenous leukemia.
  • Author(s): Uehara E, Takeuchi S, Yang Y, Fukumoto T, Matsuhashi Y, Tamura T, Matsushita M, Nagai M, Koeffler HP, Tasaka T
  • Journal Title: Oncology Letters in press
  • Peer Reviewed
• [Presentation] 造血器悪性腫瘍におけるMLH1遺伝子の異常メチル化 (2008)
  • Author(s): 松下雅英、武内世生、松下千世、小松直樹、池添隆之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-02