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2010 Fiscal Year Final Research Report

Development of novel tumor-associated antigens peptide vaccine inducing a graft-versus-leukemia effect after umbilical cord blood transplantation

Research Project

  • PDF
Project/Area Number 20591146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKanazawa University

Principal Investigator

KONDO Yukio  Kanazawa University, 附属病院, 助教 (10322116)

Project Period (FY) 2008 – 2010
Keywords腫瘍関連抗原 / ワクチン療法 / 臍帯血移植 / 樹状細胞 / 白血病 / 癌 / GITRL
Research Abstract

The expression of GITRL was observed both on leukemic cells and leukemic dendritic cells. The binding of GITRL to GITR on T cells inhibited induction of CDK2, One of the leukemia-associated antigens, -specific cytotoxic T cells (CTL) and restrained CTL activity. The GITR/GITRL interaction also increased indoleamine 2, 3-dioxygenase (IDO) activity even in leukemic cells and inducing kynurenine secretion from leukemic cells. The administration of anti-IDO agents or anti-GITRL blocking Abs combined with CDK2 vaccination may therefore effectively induce CDK2-specific CTLs in unrelated cord blood transplantation recipients.

  • Research Products

    (7 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T cells by Increasing Indoleamine 2, 3-Dioxygenase (IDO) Activity Leading to Kynurenine Secretion.2009

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Journal Title

      BLOOD 114

      Pages: 1379

    • Peer Reviewed
  • [Journal Article] GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+ T Cells.2008

    • Author(s)
      Kondo Y, Katagiri T, Ohata K, Nakao S
    • Journal Title

      BLOOD 112

      Pages: 817-818

    • Peer Reviewed
  • [Presentation] GITR-GITRリガンド結合を介した白血病細胞によるCTL の抑制:白血病細胞内インドールアミン酸素添加酵素(IDO)の関与2010

    • Author(s)
      近藤恭夫、ルイス エスピノーザ、片桐孝和、中尾眞二
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2010-02-20
  • [Presentation] GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T cells by Increasing Indoleamine 2, 3-Dioxygenase (IDO) Activity Leading to Kynurenine Secretion.2009

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Organizer
      51st annual meeting of the American Society of Hematology.
    • Place of Presentation
      Ernest N.Memorial Convention Center (USA)
    • Year and Date
      2009-12-06
  • [Presentation] 血病細胞は抑制性補助刺激分子を発現してLAAs特異的CTLの誘導を抑制する2009

    • Author(s)
      近藤恭夫、大畑欣也、祁志栄、中尾眞二
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-25
  • [Presentation] GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+ T Cells.2008

    • Author(s)
      近藤恭夫, 片桐孝和, 大畑欣也, 中尾眞二
    • Organizer
      50th annual meeting of the American Society of Hematology.
    • Place of Presentation
      Moscone Convention Center (USA)
    • Year and Date
      2008-12-09
  • [Presentation] 白血病細胞由来樹状細胞は健常者のT細胞を刺激してCDK2ペプチド特異的CTLを誘導する2008

    • Author(s)
      近藤恭夫、大畑欣也、石山謙、中尾眞二
    • Organizer
      第3回血液腫瘍免疫フォーラム
    • Place of Presentation
      大和屋(愛媛県)
    • Year and Date
      2008-04-06

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Published: 2012-01-26   Modified: 2016-04-21  

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