2010 Fiscal Year Final Research Report
Development of novel tumor-associated antigens peptide vaccine inducing a graft-versus-leukemia effect after umbilical cord blood transplantation
| Project/Area Number |
20591146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kanazawa University |
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Principal Investigator |
KONDO Yukio Kanazawa University, 附属病院, 助教 (10322116)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腫瘍関連抗原 / ワクチン療法 / 臍帯血移植 / 樹状細胞 / 白血病 / 癌 / GITRL |
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| Research Abstract |
The expression of GITRL was observed both on leukemic cells and leukemic dendritic cells. The binding of GITRL to GITR on T cells inhibited induction of CDK2, One of the leukemia-associated antigens, -specific cytotoxic T cells (CTL) and restrained CTL activity. The GITR/GITRL interaction also increased indoleamine 2, 3-dioxygenase (IDO) activity even in leukemic cells and inducing kynurenine secretion from leukemic cells. The administration of anti-IDO agents or anti-GITRL blocking Abs combined with CDK2 vaccination may therefore effectively induce CDK2-specific CTLs in unrelated cord blood transplantation recipients.
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