2010 Fiscal Year Final Research Report
The molecular mechanisms of the incomplete adaptability for social behaviors in developmental disorders and the development of diagnosis and treatment.
| Project/Area Number |
20591224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kochi University |
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Principal Investigator |
MITSUI Shinichi Kochi University, 教育研究部・医療学系, 准教授 (20295661)
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| Co-Investigator(Kenkyū-buntansha) |
YURI Kazunari 高知大学, 教育研究部・医療学系, 教授 (10220534)
OSAKO Yoji 高知大学, 教育研究部・医療学系, 助教 (40335922)
HOSOKAWA Sadatoshi 高知大学, 教育研究部・医療学系, 助教 (10380312)
ADACHI Kiyomi 高知大学, 教育研究部・医療学系, 助教 (60335932)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 発達小児科学 / 精神遅滞 / 発達障害 / motopsin / neurotrypsin / プロテアーゼ |
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| Research Abstract |
Our data suggested the following subjects. Abnormal response to social stimulation at the hippocampus of motopsin-deficient mice, known as a model for developmental disorder, appears to be derived from the cognitive deficit to olfactory stimulation. The interaction between motopsin and sez-6 may modulate the development of neuronal processes. Further, proteomic analysis of hippocampus in motopsin-deficient mice identified some candidates for motopsin substrates.
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[Journal Article] A mental retardation gene, motopsin/neurotrypsin/prssl2, modulates hippocampal function and social interaction.2009
Author(s)
Mitsui, S., Osako, Y., Yokoi, F., Dang, M.T., Yuri, K., Li, Y., Yamaguchi, N.
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Journal Title
European Journal of Neuroscience 30
Pages: 2368-2378
Peer Reviewed
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