2010 Fiscal Year Final Research Report
Analysis of the mechanism of infantile allergic diseases using the system to differentiate human ES cells into immune cells
| Project/Area Number |
20591244
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MA Hou The University of Tokyo, 医科学研究所, 特任研究員 (20378748)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUJI Kohichiro 東京大学, 医科学研究所, 准教授 (50179991)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | ヒト胚性幹細胞(ES細胞) / 乳児アレルギー疾患 / 肥満細胞 / 好酸球 |
|---|
| Research Abstract |
We succeeded the production of human mast cells and eosinophils, major immune effecter cells in allergic diseases, from hematopoietic cells derived human ES cells by coculture with AGMs-3 cells which are stromal cell line established from murine embryonic AGM region. Since this system reflect the generation and development of these immune cells in human embryo, it is expected to be a useful tool for analysis of the mechanism causing infantile allergic diseases.
|
-
[Journal Article] Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents inTokyo, Japan.2011
Author(s)
Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y
-
Journal Title
J Clinic Microbiol (掲載確定)
Peer Reviewed
-
-
-
-
[Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010
Author(s)
Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Z, Okuda T, Oda H, Tsuji K, Honda H H
-
Journal Title
Dev Biol 345
Pages: 226-236
Peer Reviewed
-
-
[Journal Article] Cardiovascular toxicity of cryopreserved cord blood cell infusion.2008
Author(s)
Konuma T, Konuma T, Ooi J, Takahashi S, Tomonari A, Tsukada N, Kobayashi T, Sato A, Kato S, Kasahara S, Ebihara Y, Nagamura-Inoue T, Tsuji K, Tojo A, Asano S
-
Journal Title
Bone Marrrow Transplant 41
Pages: 861-865
Peer Reviewed
-
[Journal Article] Direct development of functionally mature tryptase/chymase double positive connective tissue-type mast cells from primate ES cells.2008
Author(s)
Ma F, Kambe N, Wang D, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T
-
Journal Title
Stem Cells 26(3)
Pages: 706-714
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] ホームページ等
-
-
-
-
-
