2010 Fiscal Year Final Research Report
Mechanism of therapy-resistant GVHD and its treatment strategy
| Project/Area Number |
20591246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAGASAWA Masayuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座教員 (90262196)
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| Project Period (FY) |
2008 – 2010
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| Keywords | GVHD / Jun kinase / MEKK2 / 活性化T細胞 / JurkatT細胞 / カルシニューリン阻害剤 |
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| Research Abstract |
Jun kinase (Jnk) is an important kinase that is involved in T cell activation, proliferation and IL-2 production. We have found that Jnk activation by anti-CD3 plus anti-CD28 stimulation is enhanced in activated T cells compared to resting T cells. Although MEKK2 is important in Jnk activation, phosphorylated MKK4 in activated T cells, which is not found in resting T cells seems to be involved in enhanced Jnk activation. Jnk activation in activated T cells is not inhibited enough by calcineurin inhibitor, and this may explain some part of therapy-resistant GVHD.
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