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2010 Fiscal Year Final Research Report

The role of Hic-5 in intractable glomerulonephritis in children

Research Project

  • PDF
Project/Area Number 20591277
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokushima

Principal Investigator

KONDO Shuji  The University of Tokushima, ヘルスバイオサイエンス研究部 (00380080)

Co-Investigator(Kenkyū-buntansha) KAGAMI Shoji  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00224337)
Project Period (FY) 2008 – 2010
Keywords小児腎 / 泌尿器学 / 細胞・組織 / シグナル伝達 / 細胞接着分子 / 糸球体腎炎 / 病理学
Research Abstract

The purpose of this research is to clarify the expression of Hic-5 in nephritic glomeruli and how Hic-5 affects mesangial cell (MC) function. Immunohistochemistry showed that the expression of Hic-5 was increased in MC in human and rat mesangial proliferative glomerulonephritis (GN). Hic-5 expression was significantly correlated with extracellular matrix (ECM) accumulation and glomerular cell number in patients and GN rats. TGF- up-regulated Hic-5 protein levels by human cultured MCs. Knockdown of Hic-5 by siRNA reduced ECM remodeling in collagen gels. Thus, our findings suggest that Hic-5 is involved in the development of glomerulonephritis. Controlling Hic-5 activity might be a therapy strategy for GN.

  • Research Products

    (18 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Angiotensin II type I receptor blockade suppresses glomerular RAS activation, oxidative stress, and glomerular injury in crescentic glomerulonephritis.2011

    • Author(s)
      Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S.
    • Journal Title

      Translational Res (in press)

    • Peer Reviewed
  • [Journal Article] A case of a 6-year-old girl with anti-neutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis.2011

    • Author(s)
      Shimizu M, Sekiguchi T, Kishi N, Goji A, Takahashi T, Kozan H, Sakaguchi Z, Kinoshita Y, Matsuura S, Suga K, Urushihara M, Kondo S, Kagami S, Ohara K.
    • Journal Title

      Clin Exp Nephrol. (in press)

    • Peer Reviewed
  • [Journal Article] Progress of pediatric nephrology.2011

    • Author(s)
      Kondo S, Urushihara M, Kagami S.
    • Journal Title

      Nippon Jinzo Gakkai Shi. 53(1)

      Pages: 10-4

    • Peer Reviewed
  • [Journal Article] ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis.2010

    • Author(s)
      Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, Kitamura A, Matsuura S, Yoshizumi M, Tamaki T, Kawachi H, Kagami S.
    • Journal Title

      Am J Physiol Renal Physiol. 298

      Pages: F167-176

    • Peer Reviewed
  • [Journal Article] Urinary angiotensinogen accurately reflects intrarenal Renin-Angiotensin system activity.2010

    • Author(s)
      Urushihara M, Kondo S, Kagami S, Kobori H.
    • Journal Title

      Am J Nephrol. 31

      Pages: 318-325

    • Peer Reviewed
  • [Journal Article] A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency.2010

    • Author(s)
      Suga K, Kondo S, Matsuura S, Kinoshita Y, Kitano E, Hatanaka M, Kitamura H, Hidaka Y, Oda T, Kagami S.
    • Journal Title

      Pediatr Nephrol. 25

      Pages: 1547-1550

    • Peer Reviewed
  • [Journal Article] Low-density lipoprotein apheresis in a pediatric patient with refractory nephrotic syndrome due to focal segmental glomerulosclerosis.2009

    • Author(s)
      Oto J, Suga K, Matsuura S, Kondo S, Ohnishi Y, Inui D, Imanaka H, Kagami S, Nishimura M.
    • Journal Title

      J Anesth. 23

      Pages: 284-287

    • Peer Reviewed
  • [Journal Article] Rescue of renal hypoplasia and cystic dysplasia in Bcl-2-/- mice expressing Bcl-2 in ureteric bud derived epithelia.2008

    • Author(s)
      Kondo S, Oakes MG, Sorenson CM.
    • Journal Title

      Dev Dyn. 237

      Pages: 2450-2459

    • Peer Reviewed
  • [Journal Article] Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.2008

    • Author(s)
      Kondo S, Tang Y, Scheef EA, Sheibani N, Sorenson CM.
    • Journal Title

      Am J Physiol Cell Physiol. 294

      Pages: C1521-1530

    • Peer Reviewed
  • [Journal Article] Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats.2008

    • Author(s)
      Kanematsu Y, Yamaguchi K, Ohnishi H, Motobayashi Y, Ishizawa K, Izawa Y, Kawazoe K, Kondo S, Kagami S, Tomita S, Tsuchiya K, Tamaki T.
    • Journal Title

      Am J Physiol Renal Physiol. 295

      Pages: F1457-1462

    • Peer Reviewed
  • [Journal Article] Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy.2008

    • Author(s)
      Takamatsu M, Urushihara M, Kondo S, Shimizu M, Morioka T, Oite T, Kobori H, Kagami S.
    • Journal Title

      Pediatr Nephrol. 23

      Pages: 1257-1267

    • Peer Reviewed
  • [Presentation] Expression and localization of focal adhesion proteins in the developing rat kidney.2010

    • Author(s)
      Matsuura S, Kondo S, Suga K, Kinoshita Y, Tamaki T, Kagami S
    • Organizer
      The 15th Congress of the International Pediatric Nephrology Association (IPNA)
    • Year and Date
      20100829-20100902
  • [Presentation] Candesartan Suppresses Glomerular Renin-Angiotensin System (RAS) Activation, Oxidative Stress and Progressive Glomerular Injury in Rat Anti-GBM GN2010

    • Author(s)
      Kinoshita Y, Kondo S, Suga K, Matsuura S, Urushihara M, Kagami S
    • Organizer
      The 15th Congress of the International Pediatric Nephrology Association (IPNA)
    • Year and Date
      20100829-20100902
  • [Presentation] Enhanced expression of Hic-5 is involved in the development of human and rat mesangioproliferative glomerulonephritis.2010

    • Author(s)
      Kondo S, Suga K, Matsuura S, Kinoshita Y, Urushihara M, Tamaki T, Kagami S
    • Organizer
      ISN-Nexus Kyoto Symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      20100415-20100418
  • [Presentation] Expression and localization of proteins in focal adhesion in the developing rat kidney.2009

    • Author(s)
      Kondo S, Suga K, Matuura S, Kinoshita Y, Tamaki T, Kagami S
    • Organizer
      The American Society of Nephrology Renal Week 2009
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      20091027-20091101
  • [Presentation] Enhanced expression of Hydrogen peroxide-inducible clone-5 (Hic-5) on activated mesangial cells in human glomerulonephritis.2008

    • Author(s)
      Suka K, Kondo S, Matsuura S, Kinoshita Y, Urushihara M, Tamaki T, Kagami S
    • Organizer
      The American Society of Nephrology Renal Week 2008
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Year and Date
      20081104-20081109
  • [Presentation] The Expression of Hic-5 Is Involved in the Development of Progressive Glomerulonephritis in the Rat.2008

    • Author(s)
      Kondo S, Suka K, Matsuura S, Kinoshita Y, Urushihara M, Tamaki T, Kawachi H, Kagami S
    • Organizer
      The American Society of Nephrology Renal Week 2008
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Year and Date
      20081104-20081109
  • [Remarks] ホームページ等

    • URL

      http://www.tokudai-pediatrics.net/

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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