2010 Fiscal Year Final Research Report
The role of Hic-5 in intractable glomerulonephritis in children
| Project/Area Number |
20591277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KONDO Shuji The University of Tokushima, ヘルスバイオサイエンス研究部 (00380080)
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| Co-Investigator(Kenkyū-buntansha) |
KAGAMI Shoji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00224337)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児腎 / 泌尿器学 / 細胞・組織 / シグナル伝達 / 細胞接着分子 / 糸球体腎炎 / 病理学 |
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| Research Abstract |
The purpose of this research is to clarify the expression of Hic-5 in nephritic glomeruli and how Hic-5 affects mesangial cell (MC) function. Immunohistochemistry showed that the expression of Hic-5 was increased in MC in human and rat mesangial proliferative glomerulonephritis (GN). Hic-5 expression was significantly correlated with extracellular matrix (ECM) accumulation and glomerular cell number in patients and GN rats. TGF- up-regulated Hic-5 protein levels by human cultured MCs. Knockdown of Hic-5 by siRNA reduced ECM remodeling in collagen gels. Thus, our findings suggest that Hic-5 is involved in the development of glomerulonephritis. Controlling Hic-5 activity might be a therapy strategy for GN.
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Research Products
(18 results)
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[Journal Article] Angiotensin II type I receptor blockade suppresses glomerular RAS activation, oxidative stress, and glomerular injury in crescentic glomerulonephritis.2011
Author(s)
Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S.
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Journal Title
Translational Res (in press)
Peer Reviewed
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[Journal Article] A case of a 6-year-old girl with anti-neutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis.2011
Author(s)
Shimizu M, Sekiguchi T, Kishi N, Goji A, Takahashi T, Kozan H, Sakaguchi Z, Kinoshita Y, Matsuura S, Suga K, Urushihara M, Kondo S, Kagami S, Ohara K.
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Journal Title
Clin Exp Nephrol. (in press)
Peer Reviewed
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[Journal Article] ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis.2010
Author(s)
Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, Kitamura A, Matsuura S, Yoshizumi M, Tamaki T, Kawachi H, Kagami S.
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Journal Title
Am J Physiol Renal Physiol. 298
Pages: F167-176
Peer Reviewed
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[Journal Article] Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats.2008
Author(s)
Kanematsu Y, Yamaguchi K, Ohnishi H, Motobayashi Y, Ishizawa K, Izawa Y, Kawazoe K, Kondo S, Kagami S, Tomita S, Tsuchiya K, Tamaki T.
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Journal Title
Am J Physiol Renal Physiol. 295
Pages: F1457-1462
Peer Reviewed
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