Therapeutic research for psychiatric disorders by rTMS with simultaneous monitoring of regional cerebral blood volume using NIRS

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20591402
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: MASAO Iwase Osaka University, 医学系研究科, 助教 (60362711)
• Project Period (FY): 2008 – 2011
• Keywords: 磁気刺激 / 近赤外分光法 / 遺伝子解析 / 精神生理学 / 非薬物療法

Research Abstract

本研究課題では近赤外分光法(NIRS)による脳血流測定を同時に行いながら反復的経頭蓋磁気刺激治療(rTMS)を精神疾患に対して行い、治療効果と磁気刺激中の脳血流変化との関連を明らかにし、rTMSの有効性を高める方法を探索する。

Research Products

• [Journal Article] Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks : A near-infrared spectroscopy (2010)
  • Author(s): Azechi M, Iwase M, Ikezawa K, Takahashi H, Canuet L, Kurimoto R, Nakahachi T, Ishii R, Fukumoto M, Ohi K, Yasuda Y, Kazui H, Hashimoto R, Takeda M.
  • Journal Title: Schizophrenia Research 117 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. (2010)
  • Author(s): Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M
  • Journal Title: Psychophysiology 47 Pages: 831-837
  • Peer Reviewed
• [Journal Article] Frontal cortex activation associated with speeded processing of visuospatial working memory revealed by multichannel near-infrared spectroscopy during Advanced Trail Making Test performance (2010)
  • Author(s): Nakahachi T, Ishii R, Iwase M, Canuet L, Takahashi H, Kurimoto R, Ikezawa K, Azechi M, Kajimoto O, Takeda M.
  • Journal Title: Behav Brain Res 15 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks : A two-channel near-infrared spectroscopy study. (2009)
  • Author(s): Ikezawa K, Iwase M, Ishii R, Azechi M, Canuet L, Ohi K, Yasuda Y, Iike N, Kurimoto R, Takahashi H, Nakahachi T, Sekiyama R, Yoshida T, Kazui H, Hashimoto R, Takeda M.
  • Journal Title: Schizophrenia Ressearch 108 Pages: 93-103
  • Peer Reviewed
• [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia (2008)
  • Author(s): Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M.
  • Journal Title: Neuroscience Research 62 Pages: 187-194
  • Peer Reviewed
• [Presentation] Two-channel near infrared spectroscopy (NIRS) activation curves of oxyhemoglobin during frontal lobe tasks in schizophrenia. (2010)
  • Author(s): Iwase M, et al.
  • Organizer: 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] Two-channel NIRS activation curves of oxyhemoglobin during frontal lobe tasks in schizophrenia. (2010)
  • Author(s): Iwase M, et al.
  • Organizer: The 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-10-28
• [Presentation] Endophenotypes of schizophrenia : current condition (2010)
  • Author(s): Iwase M et al
  • Organizer: 第33回日本神経科学会大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] Two-chanel near infrared spectroscopy (NIRS) activation timing curves of oxyhemoglobin during frontal tasks in schizophrenia. (2010)
  • Author(s): Iwase M, et al.
  • Organizer: 2nd Biennial Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-04-12
• [Presentation] Hypofrontality in schizophrenia detected by the measurement of tissue oxygeneation index using NIRS. (2009)
  • Author(s): Iwase M, et al.
  • Organizer: The 32nd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya
  • Year and Date: 2009-09-18
• [Book] 精神医学への招待(第3版) (2011)
  • Author(s): 志水彰、頼藤和寛、水田一郎、岩瀬真生
  • Total Pages: 1-252
  • Publisher: 南山堂
• [Book] 看護学テキストNICE疾病と治療III、第XIV章(精神の症状・徴候と疾患1精神の症状・兆候C.幻覚・妄想) (2010)
  • Author(s): 岩瀬真生
  • Total Pages: 212-213
  • Publisher: 南江堂
• [Book] 精神疾患とNIRS(福田正人(編)) (2009)
  • Author(s): 池澤浩二、岩瀬真生、疇地道代
  • Total Pages: 177-184
  • Publisher: 中山書店
• [Book] Fatigue Science for Human Health(Eds.Watanabe Y, Evengard B, Natelson BH, Jason LA, Kuratsune H) (2008)
  • Author(s): Iwase M, et al.
  • Total Pages: 103-117
  • Publisher: Springer Japan
• [Book] ストレスの科学と健康(二木鋭雄編) (2008)
  • Author(s): 岩瀬真生
  • Total Pages: 162-165
  • Publisher: 共立出版