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2011 Fiscal Year Final Research Report

Transcranial magnetic stimulation in psychiatric disorders with simultaneous monitoring of cerebral blood volume by near infra-red spectroscopy

Research Project

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Project/Area Number 20591402
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

IWASE Masao  大阪大学, 医学系・研究科, 助教 (60362711)

Co-Investigator(Kenkyū-buntansha) ISHII Ryouhei  大阪大学, 医学系・研究科, 助教 (40372619)
TAKAHASHI Hidetoshi  大阪大学, 医学部附属病院, 医員 (40423222)
TAKEDA Masatoshi  大阪大学, 医学系・研究科, 教授 (00179649)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Ryota  大阪大学, 連合小児発達学研究科, 准教授 (10370983)
Project Period (FY) 2008 – 2011
Keywords磁気刺激 / 近赤外分光法 / 遺伝子解析 / 精神生理学 / 非薬物療法
Research Abstract

Repetitive transcranial magnetic stimulation(rTMS) was performed in patients with psychiatric disorders. During rTMS, blood volume change was observed using simultaneous monitoring by near infra-red spectroscopy(NIRS). In several cases, NIRS measurement was confounded by artifacts. NIRS measurement could discriminate healthy controls with patients with psychiatric disorders and could be applied to the prediction of efficacy of rTMS treatment.

  • Research Products

    (74 results)

All 2012 2011 2010 2009 2008

All Journal Article (35 results) (of which Peer Reviewed: 35 results) Presentation (32 results) Book (7 results)

  • [Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects2012

    • Author(s)
      Takahashi H et al
    • Journal Title

      Neurosci Res

      Volume: 72 Pages: 187-9

    • Peer Reviewed
  • [Journal Article] Prepulse inhibition of startle response : recent advances in human studies of psychiatric disease2011

    • Author(s)
      Takahashi H et al
    • Journal Title

      Clin Psychopharmacol Neursoci

      Volume: 9 Pages: 102-10

    • Peer Reviewed
  • [Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage2011

    • Author(s)
      Kazui H et al
    • Journal Title

      Dement Geriatr Cogn Dis Extra

      Volume: 1 Pages: 20-30

    • Peer Reviewed
  • [Journal Article] Variants of the RELA gene are associated with schizophrenia and their startle responses2011

    • Author(s)
      Hashimoto R et al
    • Journal Title

      Neuropsychopharmacology

      Volume: 36 Pages: 1921-31

    • Peer Reviewed
  • [Journal Article] Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia : A magnetoencephalography-beamformer study2011

    • Author(s)
      Ikezawa K, et al
    • Journal Title

      Neurosci Res

      Volume: 71 Pages: 235-43

    • Peer Reviewed
  • [Journal Article] Resting-State EEG Source Localization and Functional Connectivity in Schizophrenia-like Psychosis of Epilepsy2011

    • Author(s)
      Canuet L et al
    • Journal Title

      PLoS One

      Volume: 6 Pages: e27863

    • Peer Reviewed
  • [Journal Article] The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex2011

    • Author(s)
      Ohi K et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Pages: 1309-15

    • Peer Reviewed
  • [Journal Article] Psychopathology and working memory-induced activation of the prefrontal cortex in schizophrenia-like psychosis of epilepsy : Evidence from magnetoencephalography2011

    • Author(s)
      Canuet L et al
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65 Pages: 183-90

    • Peer Reviewed
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011

    • Author(s)
      Ohi K et al
    • Journal Title

      World J Biol Psychiatry

      Volume: Epubahead of print

    • Peer Reviewed
  • [Journal Article] Frontal shift of posterior alpha activity is correlated with cognitive impairment in early Alzheimer' s disease : a magnetoencephalography-beamformer study2010

    • Author(s)
      Ishii R et al
    • Journal Title

      Psychogeriatric

      Volume: 10 Pages: 138-143

    • Peer Reviewed
  • [Journal Article] Frontal cortex activation associated with speeded processing of visuospatial working memory revealed by multichannel near-infrared spectroscopy during Advanced Trail Making Test performance2010

    • Author(s)
      Nakahachi T et al
    • Journal Title

      Behav Brain Res

      Volume: 215 Pages: 21-27

    • Peer Reviewed
  • [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population2010

    • Author(s)
      Yasuda Y et al
    • Journal Title

      World J Biol Psychiatry

      Volume: 11 Pages: 852-857

    • Peer Reviewed
  • [Journal Article] Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder : an MEG study2010

    • Author(s)
      Honaga E et al
    • Journal Title

      Neurosci Lett

      Volume: 478 Pages: 141-145

    • Peer Reviewed
  • [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects2010

    • Author(s)
      Takahashi H et al
    • Journal Title

      Psychophysiology

      Volume: 47 Pages: 831-837

    • Peer Reviewed
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia : evidence from a multi-center case-control study and meta-analysis2010

    • Author(s)
      Ohi K et al
    • Journal Title

      Schizophrenia Res

      Volume: 116 Pages: 126-132

    • Peer Reviewed
  • [Journal Article] Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography2010

    • Author(s)
      Canuet L et al
    • Journal Title

      Epilepsy Behav

      Volume: 17 Pages: 109-119

    • Peer Reviewed
  • [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene2010

    • Author(s)
      Yasuda Y et al
    • Journal Title

      Neurosci Lett

      Volume: 495 Pages: 216-20

    • Peer Reviewed
  • [Journal Article] No Association between PCM1 Gene and Schizophrenia : a Multi-Center Case-Control Study in a Japanese Population and a Meta-Analysis2010

    • Author(s)
      Hashimoto R et al
    • Journal Title

      Schizophrneia Res

      Volume: 129 Pages: 80-4

    • Peer Reviewed
  • [Journal Article] Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks : A near-infrared spectroscopy2010

    • Author(s)
      Azechi M et al
    • Journal Title

      Schizophrenia Research

      Volume: 117 Pages: 52-60

    • Peer Reviewed
  • [Journal Article] TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function. Genes2009

    • Author(s)
      Ohi K et al
    • Journal Title

      Brain and Behavior

      Volume: 8 Pages: 473-480

    • Peer Reviewed
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia : evidence from a multi-center case-control study and meta-analysis2009

    • Author(s)
      Ohi K et al
    • Journal Title

      Schizophrenia Research

      Volume: 116 Pages: 126-132

    • Peer Reviewed
  • [Journal Article] Factors associated with impaired quality of life in younger and older adults with epilepsy2009

    • Author(s)
      Canuet L et al
    • Journal Title

      Epilepsy Research

      Volume: 83 Pages: 58-65

    • Peer Reviewed
  • [Journal Article] Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography2009

    • Author(s)
      Ishii R et al
    • Journal Title

      Clinical Neurophysiology

      Volume: 120 Pages: 497-504

    • Peer Reviewed
  • [Journal Article] Association study of the G72 gene with schizophrenia in a Japanese population : A multicenter study2009

    • Author(s)
      Ohi K et al
    • Journal Title

      Schizophrenia Research

      Volume: 109 Pages: 80-85

    • Peer Reviewed
  • [Journal Article] Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks : A two-channel near-infrared spectroscopy study2009

    • Author(s)
      Ikezawa K et al
    • Journal Title

      Schizophrenia Ressearch

      Volume: 108 Pages: 93-103

    • Peer Reviewed
  • [Journal Article] Severity of depressive symptoms as predictor of impairment of quality of life in chronic migraine : comparison with episodic migraine2009

    • Author(s)
      Canuet L et al
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 62 Pages: 738-40

    • Peer Reviewed
  • [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia2008

    • Author(s)
      Takahashi H et al
    • Journal Title

      Neuroscience Research

      Volume: 62 Pages: 187-94

    • Peer Reviewed
  • [Journal Article] Tuberous sclerosis : localizing the epileptogenic tuber with synthetic aperture magnetometry with excess kurtosis analysis2008

    • Author(s)
      Canuet L et al
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 15 Pages: 1296-8

    • Peer Reviewed
  • [Journal Article] Spatially filtered magnetoencephalography compared with electrocorticography to identify intrinsically epileptogenic focal cortical dysplasia2008

    • Author(s)
      Ishii R et al
    • Journal Title

      Epilepsy Research

      Volume: 81 Pages: 228-32

    • Peer Reviewed
  • [Journal Article] Frontal activity during the digit symbol substitution test determined by multichannel near-infrared spectroscopy2008

    • Author(s)
      Nakahachi T et al
    • Journal Title

      Neuropsychobiology

      Volume: 57 Pages: 151-8

    • Peer Reviewed
  • [Journal Article] Event-related synchronization of alpha activity in early Alzheimer' s disease and mild cognitive impairment : an MEG study combining beamformer and group comparison2008

    • Author(s)
      Kurimoto R et al
    • Journal Title

      Neuroscience Letter

      Volume: 443 Pages: 86-9

    • Peer Reviewed
  • [Journal Article] Cephalic auras of supplementary motor area origin : an ictal MEG and SAM(g2) study2008

    • Author(s)
      Canuet L et al
    • Journal Title

      Epilepsy and Behavior

      Volume: 13 Pages: 570-4

    • Peer Reviewed
  • [Journal Article] Disturbed Holistic Processing in Autism Spectrum Disorders Verified by Two Cognitive Tasks Requiring Perception of Complex Visual Stimuli2008

    • Author(s)
      Nakahachi T et al
    • Journal Title

      Psychiatry Research

      Volume: 159 Pages: 330-8

    • Peer Reviewed
  • [Journal Article] Brain oscillatory activity in depressed epilepsy patients2008

    • Author(s)
      Ishii R et al
    • Journal Title

      Brain Topography

      Volume: 20 Pages: 161-162

    • Peer Reviewed
  • [Journal Article] Efficacy of risperidone in the treatment of delirium in elderly patients2008

    • Author(s)
      Ikezawa K et al
    • Journal Title

      Psychogeriatrics

      Volume: 8 Pages: 62-65

    • Peer Reviewed
  • [Presentation] Sternberg課題中の前頭部血流変化のNIRSによる測定2011

    • Author(s)
      岩瀬真生
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2011-11-10
  • [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses2011

    • Author(s)
      Ohi K et al
    • Organizer
      2nd Congress of AsCNP(Asian College of Neuropsychopharmacologoy)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-09-24
  • [Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia2011

    • Author(s)
      Hashimoto R et al
    • Organizer
      2nd Congress of AsCNP(Asian College of Neurophychopharmacologoy)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-09-23
  • [Presentation] The KCNH2 gene is associated with neurocognition and the risk of Schizophrenia2011

    • Author(s)
      Ohi K et al
    • Organizer
      19th World Congress of Psychiatric Genetics
    • Place of Presentation
      Washington D. C., USA
    • Year and Date
      2011-09-14
  • [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses2011

    • Author(s)
      Hashimoto R et al
    • Organizer
      19th World Congress of Psychiatric Genetics
    • Place of Presentation
      Washington D. C., USA
    • Year and Date
      2011-09-10
  • [Presentation] Relationship of prepulse inhibition to opersonality dimensions in Japanese patients with schizophrenia2011

    • Author(s)
      Takahashi H et al
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2011-06-01
  • [Presentation] The KCNH2 Gene Is Associated with Neurocognition and the Risk of Schizophrenia2011

    • Author(s)
      Ohi K et al
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2011-05-29
  • [Presentation] Cognitive and psychopathological disturbance in schizophrenia-like epilepsy psychosis : a neuroimaging magnetoencephalography study2011

    • Author(s)
      Canuet L et al
    • Organizer
      2nd Asian Congress on Schizophrenia Research
    • Place of Presentation
      The Ritz Carlton Soeul, Soeul, South Korea
    • Year and Date
      2011-02-11
  • [Presentation] Two-channel near infrared spectroscopy activation curves of oxyhemoglobin during frontal lobe tasks in schizophrenia2010

    • Author(s)
      Iwase M et al
    • Organizer
      40th Annual Meeting, Neuroscience 2010
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2010-11-14
  • [Presentation] Depressive state : the strongest predictor of quality of life in elderly patients with epilepsy2010

    • Author(s)
      Canuet L et al
    • Organizer
      The Hong Kong Psychogeriatric Association Annual Scientific Meeting cum Annual General Meeting
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2010-11-06
  • [Presentation] Two-channel NIRS activation curves of oxyhemoglobin during frontal lobe tasks in schizophrenia2010

    • Author(s)
      Iwase M et al
    • Organizer
      The 29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-11-01
  • [Presentation] Frontal lobe dysfunction and regional hemodynamic changes in major depression : A near infrared spectroscopy study2010

    • Author(s)
      Azechi M et al
    • Organizer
      The 29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-10-28
  • [Presentation] Platform presentation : Psychiatry & Neuropsychology. Working memory-induced activation and severity of psychopathology in schizophrenia-like psychosis of epilepsy : evidence from magnetoencephalography2010

    • Author(s)
      Canuet L et al
    • Organizer
      The 8th Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Melbourne, Austlaria
    • Year and Date
      2010-10-21
  • [Presentation] Spatially filtered MEG revealed theta and gamma power changes during mental calculation2010

    • Author(s)
      Ishii R et al
    • Organizer
      第33回日本神経科学会大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
  • [Presentation] Endophenotypes of schizophrenia : current condition2010

    • Author(s)
      Iwase M et al
    • Organizer
      第33回日本神経科学会大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
  • [Presentation] Two-channel near infrared spectroscopy activation curves of oxyhemoglobin during frontal tasks in schizophrenia2010

    • Author(s)
      Iwase M et al
    • Organizer
      第33回日本神経科学会大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-02
  • [Presentation] Two-channel near infrared spectroscopy(NIRS) activation timing curves of oxyhemoglobin during frontal tasks in schizophrenia2010

    • Author(s)
      Iwase M et al
    • Organizer
      2nd Biennial Schizophrenia International Research Society Conference
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-04-12
  • [Presentation] 2-ch-NIRSによる前頭葉課題施行中の酸化ヘモグロビン濃度の賦活曲線特性-統合失調症と健常者の比較2009

    • Author(s)
      岩瀬真生
    • Organizer
      第39回日本臨床神経生理学会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2009-11-18
  • [Presentation] 近赤外分光法による組織酸素化指標を用いた統合失調症の前頭低活性の検討2009

    • Author(s)
      岩瀬真生
    • Organizer
      第16回日本未病システム学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2009-10-31
  • [Presentation] 「人はなぜ笑うのか?」:笑いの脳内メカニズム2009

    • Author(s)
      岩瀬真生
    • Organizer
      日本学術会議近畿地区会議学術講演会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2009-10-11
  • [Presentation] Hypofrontality in schizophrenia detected by the measurement of tissue oxygeneation index using NIRS2009

    • Author(s)
      Iwase M et al
    • Organizer
      The 32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-09-18
  • [Presentation] MEG source-power changes during working memory performance in chronic interictal psychosis2009

    • Author(s)
      Canuet L et al
    • Organizer
      2nd conference of International Society for the Advancement of Clinical Magnetoencephalography
    • Place of Presentation
      Greece
    • Year and Date
      2009-09-05
  • [Presentation] MEG oscillatory activity during eyes-open/ eyes-closed resting state in schizophrenia2009

    • Author(s)
      Ikezawa K et al
    • Organizer
      2nd conference of International Society for the Advancement of Clinical Magnetoencephalography
    • Place of Presentation
      Greece
    • Year and Date
      2009-09-03
  • [Presentation] Discriminant analysis in schizophrenia and healthy subjects using preforntal activation during forntal lobe tasks : a near-infrared spectroscopy study2009

    • Author(s)
      Azechi M et al
    • Organizer
      The 9th World Congress of Biological Psychiatry
    • Place of Presentation
      Paris
    • Year and Date
      2009-07-01
  • [Presentation] NIRSによる組織酸素化指標を用いた統合失調症の前頭低活性の検討2009

    • Author(s)
      岩瀬真生
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-01-31
  • [Presentation] Impaired prepulse inhibition od acoustic startle response in Japanese patients with schizophrenia2009

    • Author(s)
      Hidetoshi Takahashi et al
    • Organizer
      第1回アジア統合失調症ワークショップ
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-01-30
  • [Presentation] NIRS測定による組織酸素化指標を用いた統合失調症の前頭低活性の検討2008

    • Author(s)
      岩瀬真生
    • Organizer
      第38回日本臨床神経生理学会学術大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-11-12
  • [Presentation] Symposium-11 : Recent Neurophysiological Advances in Biological Psychiatry, Clinical application of MEG in psychiatric disorders2008

    • Author(s)
      Ryouhei Ishii et al
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      Toyama Kenmin-kaikan, Kenmin Hall
    • Year and Date
      2008-09-11
  • [Presentation] MEG findings in schizophrenia-like psychosis of epilepsy after resection of meningioma2008

    • Author(s)
      K. Ikezawa et al
    • Organizer
      The 16th International Conference on Biomagnetism
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-08-28
  • [Presentation] Shunt effectiveness in patients with iNPH predicted by MEG changes before and after lumbar tap test2008

    • Author(s)
      R. Ishii et al
    • Organizer
      The 16th International Conference on Biomagnetism
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-08-26
  • [Presentation] Beta ERD during a memory task decreased in prefrontal cortex in patients with Alzheimer' s disease and mild cognitive impairment2008

    • Author(s)
      Kurimoto R et al
    • Organizer
      The 16th International Conference on Biomagnetism
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-08-25
  • [Presentation] Ictal MEG-SAM(g2) analysis in sensory seizures of supplementary motor area origin2008

    • Author(s)
      L. Canuet et al
    • Organizer
      The 16th International Conference on Biomagnetism
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-08-25
  • [Book] 現代精神医学事典加藤敏・神庭重信他(編)2011

    • Author(s)
      岩瀬真生
    • Total Pages
      6
    • Publisher
      弘文堂
  • [Book] 精神医学への招待(第3版)2011

    • Author(s)
      志水彰ら
    • Total Pages
      1-252
    • Publisher
      南山堂
  • [Book] 看護学テキストNICE疾病と治療III、第XIV章精神の症状・徴候と疾患2精神疾患、B.アルコールによる精神障害2010

    • Author(s)
      岩瀬真生
    • Total Pages
      236-238
    • Publisher
      南江堂
  • [Book] 看護学テキストNICE疾病と治療III、第XIV章精神の症状・徴候と疾患1精神の症状・兆候C.幻覚・妄想2010

    • Author(s)
      岩瀬真生
    • Total Pages
      212-213
    • Publisher
      南江堂
  • [Book] 精神疾患とNIRS,福田正人(編)2009

    • Author(s)
      池澤浩二ら
    • Total Pages
      177-184
    • Publisher
      中山書店
  • [Book] Fatigue Science for Human Health(Eds. Watanabe Y, Evengard B, Natelson BH, Jason LA, Kuratsune H)2008

    • Author(s)
      Iwase M et al
    • Total Pages
      103-117
    • Publisher
      Springer Japan
  • [Book] トレスの科学と健康(二木鋭雄編)2008

    • Author(s)
      岩瀬真生
    • Total Pages
      162-165
    • Publisher
      共立出版

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Published: 2013-07-31  

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