Diffusion tensor imaging in patients with major depression

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: TERAE Satoshi Hokkaido University, 病院, 准教授 (40240634)
• Co-Investigator(Kenkyū-buntansha): INOUE Takeshi 北海道大学, 病院, 講師 (70250438) ; NAKAGAWA Shin 北海道大学, 病院, 講師 (60360905) ; KUDO Kohsuke 岩手医科大学, 先端科学技術研究センター, 講師 (10374232)
• Project Period (FY): 2008 – 2010
• Keywords: MRI / うつ病 / 拡散テンソル

Research Abstract

Diffusion tensor imaging (DTI) was conducted in 13 treatment-resistant, 12 nontreatment-resistant, and 19 drug-naive patients with major depression. As compared with normal control subjects, a voxel-based analysis revealed significant decrease in fractional anisotropy (FA) in the right frontal white matter in the treatment-resistant patients. Histogram analysis demonstrated significant decrease in peak position of FA histogram of the drug-naive patients. No significant correlation was observed between the FA abnormality and clinical severity as assessed by HDRS, GAF, and MADRS.

Research Products

• [Journal Article] Susceptibility of Tmax to Tracer Delay on Perfusion Analysis: Quantitative Evaluation of Various Deconvolution Algorithms Using Digital Phantoms. (2011)
  • Author(s): Kudo K, Sasaki M, Ostergaard L, Christensen S, Uwano I, Suzuki M, Ogasawara K, Shirato H, Ogawa A.
  • Journal Title: J Cereb Blood Flow Metab 31 Pages: 908-912
  • Peer Reviewed
• [Journal Article] Prediction of infarct volume and neurologic outcome by using automated multiparametric perfusion-weighted magnetic resonance imaging in a primate model of permanent middle cerebral artery occlusion. (2011)
  • Author(s): Sasaki M, Kudo K, Honjo K, Hu JQ, Wang HB, Shintaku K.
  • Journal Title: J Cereb Blood Flow Metab 31 Pages: 448-456
  • Peer Reviewed
• [Journal Article] Non-Invasive Measurement of Oxygen Saturation in the Spinal vein using SWI: Quantitative Evaluation under Conditions of Physiological and Caffeine Load. (2011)
  • Author(s): Fujima N, Kudo K, Terae S, Ishizaka K, Yazu R, Zaitsu Y, Tha KK, Yoshida K, Tsukahara A, Haacke EM, Sasaki M, Shirato H.
  • Journal Title: Neuroimage 54 Pages: 344-349
  • Peer Reviewed
• [Journal Article] High-resolution diffusion tensor imaging for the detection of diffusion abnormalities in the trigeminal nerves of patients with trigeminal neuralgia caused by neurovascular compression. (2011)
  • Author(s): Fujiwara S, Sasaki M, Wada T, Kudo K, Hirooka R, Ishigaki D, Nishikawa Y, Ono A, Yamaguchi M, Ogasawara K.
  • Journal Title: J Neuroimaging 21 Pages: e102-108
  • Peer Reviewed
• [Journal Article] Susceptibility-Weighted Imaging and Magnetic Resonance Angiography during Migraine Attack : A Case Report. (2011)
  • Author(s): Shimoda Y, Kudo K, Kuroda S, Zaitsu Y, Fujima N, Terae S, Sasaki M, Houkin K.
  • Journal Title: Magn Reson Med Sci 10 Pages: 49-52
  • Peer Reviewed
• [Journal Article] Long-term naturalistic follow-up of lithium augmentation : relevance to bipolarity. (2011)
  • Author(s): Inoue T, Abekawa T, Nakagawa S, Suzuki K, Tanaka T, Kitaichi Y, Boku S, Toda H, Koyama T
  • Journal Title: J Affect Disord 129 Pages: 64-67
  • Peer Reviewed
• [Journal Article] Pramipexole for stage 2 treatment-resistant major depression : an open study. (2010)
  • Author(s): Inoue T, Kitaichi Y, Masui T, Nakagawa S, Boku S, Tanaka T, Suzuki K, Nakato Y, Usui R, Koyama T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 34 Pages: 1446-1449
  • Peer Reviewed
• [Journal Article] In vivo topographic illustration of microstructural white matter abnormalities of multiple system atrophy by diffusion tensor imaging. (2010)
  • Author(s): Tha KK, Terae S, Yabe I, Miyamoto T, Soma H, Zaitsu Y, Fujima N, Kudo K, Sasaki H, Shirato H.
  • Journal Title: Radiology 255 Pages: 563-569
  • Peer Reviewed
• [Journal Article] Differences in CT Perfusion Maps Generated by Different Commercially Available Software : Analysis Using Identical Source Data of Acute Stroke Patients. (2010)
  • Author(s): Kudo K, Sasaki M, Yamada K, Momoshima S, Utsunomiya H, Shirato H, Ogasawara K.
  • Journal Title: Radiology 254 Pages: 200-209
  • Peer Reviewed
• [Journal Article] Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging. (2010)
  • Author(s): Sasaki M, Shibata E, Ohtsuka K, Endoh J, Kudo K, Narumi S, Sakai A.
  • Journal Title: Neuroradiology 52 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Depression and major depressive disorder in patients with Parkinson's disease. (2010)
  • Author(s): 井上猛
  • Journal Title: Movement Disorders 25 Pages: 44-49
  • Peer Reviewed
• [Journal Article] Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenuated inversion recovery images of the brain. Part II : non-pathological conditions. (2009)
  • Author(s): Tha KK, Terae S, Kudo K, Miyasaka K.
  • Journal Title: Br J Radiol 82 Pages: 610-614
  • Peer Reviewed
• [Journal Article] Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenuated inversion recovery images of the brain. Part I : pathological conditions. (2009)
  • Author(s): Tha KK, Terae S, Kudo K, Miyasaka K.
  • Journal Title: Br J Radiol 82 Pages: 426-434
  • Peer Reviewed
• [Journal Article] Difference in the Tracer Delay-Induced Effect among Deconvolution Algorithms in CT Perfusion Analysis: Quantitative Evaluation by using Digital Phantoms. (2009)
  • Author(s): Kudo K, Sasaki M, Ogasawara K, Terae S, Ehara S, Shirato H.
  • Journal Title: Radiology 251 Pages: 241-249
  • Peer Reviewed
• [Journal Article] Prospective study on the mismatch concept in acute stroke patients within the first 24h after symptom onset -1000Plus study. (2009)
  • Author(s): Hotter B, Pittl S, Ebinger M, Oepen G, Jegzentis K, Kudo K, Rozanski M, Schmidt WU, Brunecker P, Xu C, Martus P, Endres M, Jungehulsing GJ, Villringer A, Fiebach JB.
  • Journal Title: BMC Neurology 9 Pages: 60
  • Peer Reviewed
• [Journal Article] SSRI・SNRI単剤にて寛解に至らなかった単極性うつ病患者における第二選択治療の有効性に関する調査研究 (2008)
  • Author(s): 新出泰士, 中島幸治, 北市雄士, 中川伸, 井上猛, 小山司
  • Journal Title: 臨床精神薬理 11 Pages: 1887-1898
  • Peer Reviewed
• [Journal Article] Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics. (2008)
  • Author(s): Takahashi T, Oono H, Inoue T, Boku S, Kako Y, Kitaichi Y, Kusumi I, Masui T, Nakagawa S, Suzuki K, Tanaka T, Koyama T, Radford MH
  • Journal Title: Neuro Endocrinol Lett 29 Pages: 351-358
  • Peer Reviewed
• [Presentation] Accuracy and reliability of post-proces sing software for ct perfusion : quantitative analysis by digital phantom. (2010)
  • Author(s): Kudo K, Christensen S, Sasaki M, Uwano I, Sasaki T, Ogasawara K, Ostergaard L
  • Organizer: World Stroke Congress
  • Place of Presentation: COEX Center, Seoul
  • Year and Date: 2010-10-13
• [Presentation] Neuro Applications of Echelon 1.5T MRI. (2010)
  • Author(s): Kudo K.
  • Organizer: MRI Seminar in Singapore
  • Place of Presentation: Singapore
  • Year and Date: 2010-10-09
• [Presentation] Hypothalamic-pituitary-adrenal axis abnormality and hippocampal change in depressed subjects. (2010)
  • Author(s): 中川伸
  • Organizer: 第27回CINP
  • Place of Presentation: HKCEC, Convention Hall BC、香港
  • Year and Date: 2010-06-07
• [Presentation] 海馬神経細胞新生と気分障害治療 (2010)
  • Author(s): 中川伸
  • Organizer: 海馬神経細胞新生と気分障害治療
  • Place of Presentation: 広島国際会議場・アステールプラザ、広島市
  • Year and Date: 2010-05-22
• [Presentation] Accuracy and Reliability of Post-Processing Software for DSC MR Perfusion : Quantitative Analysis by Digital Phantom Data. (2010)
  • Author(s): Kudo K, Christensen S, Sasaki M, Straka M, Fujiwara S, Ishizaka K, Zaitsu Y, Fujima N, Terae S, Ogasawara K, Ostergaard L
  • Organizer: ISMRM (International Socie ty for Magnetic Resonance in Medicine)
  • Place of Presentation: Stockholmsmassan AB, Stockholm
  • Year and Date: 2010-05-01
• [Presentation] Improved Quantification of cerebral blood flow change using phase information of SWI, corrected by arterial oxygen saturation. (2010)
  • Author(s): Zaitsu Y, Kudo K, Yazu R, Ishizaka K, Fujima N, Terae S, Sasaki M, Shirato H
  • Organizer: ISMRM (International Society forMagnetic Resonance in Medicine)
  • Place of Presentation: Stockholmsmassan AB, Stockholm
  • Year and Date: 2010-05-01
• [Presentation] Impaired microstructural integrity of frontal white matter in treatment-resistant depression. (2010)
  • Author(s): Tha KK, Terae S, Inoue S, Nakagawa S, Miyamoto T, Fujima N, Zaitsu Y, Koyama T, Shirato H
  • Organizer: 22nd European Congress of Radiology
  • Place of Presentation: Austria Center Vienna, Bruno Kreisky Platz 1A-1220 Vienna, Austria
  • Year and Date: 2010-03-04
• [Presentation] うつ病の脳画像所見の臨床的意義 (2009)
  • Author(s): 井上猛
  • Organizer: 第7回北海道大学脳科学研究教育センターシンポジウム
  • Place of Presentation: 北大学術交流会館、札幌市
  • Year and Date: 2009-12-08
• [Presentation] 神経細胞新生から見た向精神薬の作用機序 (2009)
  • Author(s): 中川伸
  • Organizer: 第19回日本臨床精神薬理学会・第39回日本神経精神薬理学会合同年会(シンポジウム)
  • Place of Presentation: 国立京都国際会館、京都市
  • Year and Date: 2009-11-13
• [Presentation] Impaired microstructural white matter integrity in treatment-resistant major depression. (2009)
  • Author(s): Tha KK, Terae S, Inoue S, Nakagawa S, Miyamoto T, Kitaichi Y, Matsui T, Boku S, Fujima N, Zaitsu Y, Koyama T, Shirato H
  • Organizer: The 1stHokkaido Univ.-Academia Sinica Joint Symposium, The 7th Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: 北海道大学学術交流会館、札幌市
  • Year and Date: 2009-10-07
• [Presentation] MR灌流画像解析の標準化に向けたデジタルファントムの作成と応用 (2009)
  • Author(s): 工藤與亮、Soren Christensen、佐々木真理、藤原俊朗、Leif Ostergaard
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: パンパシフィック横浜ベイホテル東急、横浜市
  • Year and Date: 2009-10-01
• [Presentation] Impaired frontal white matter integrity in treatment-resistant depression detected by DTI. (2009)
  • Author(s): Tha KK, Terae S, Inoue S, Nakagawa S, Miyamoto T, Matsuyama T, Fujima N, Zaitsu Y, Koyama T, Shirato H
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: パンパシフィック横浜ベイホテル東急、横浜市
  • Year and Date: 2009-10-01
• [Presentation] 拡散テンソルによる難治性うつ病における大脳白質障害の検討 (2009)
  • Author(s): Tha KK、寺江聡、井上猛、中川伸、宮本環、相馬広幸、藤間憲幸、財津有里、矢部一朗、小山司、白土博樹
  • Organizer: 第120回日本医学放射線学会北日本地方会
  • Place of Presentation: ホテルニューキャッスル、弘前市
  • Year and Date: 2009-06-20
• [Presentation] 認知症とうつ病 (2009)
  • Author(s): 中川伸
  • Organizer: 北海道高齢者研究会
  • Place of Presentation: JRタワーホテル、札幌市
  • Year and Date: 2009-06-06
• [Presentation] SWI of the Spinal Veins. (2009)
  • Author(s): Kudo K.
  • Organizer: ISMRM (International Society for Magnetic Resonance in Medicine)
  • Place of Presentation: Hawaii conventioncenter, Honolulu, USA
  • Year and Date: 2009-04-18
• [Presentation] 難治性うつ病に対するドパミン作動薬の有用性 (2008)
  • Author(s): 井上猛、小山司
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会 合同年会
  • Place of Presentation: 品川プリンスホテル、東京
  • Year and Date: 2008-10-01
• [Presentation] SWIを用いた定量的脳血流マップの開発 (2008)
  • Author(s): 工藤與亮
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 旭川市民文化会館、旭川市
  • Year and Date: 2008-09-11
• [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために(神庭重信、加藤忠史編)(海馬とストレス) (2010)
  • Author(s): 中川伸
  • Total Pages: 328(72-75)
  • Publisher: 中山書店
• [Book] Recent developments on depression research.(Yukihiko Shirayama and Shigeyuiki Chaki eds.)(Possible role of adulthippocampal neurogenesis in depression and antidepressant action.) (2009)
  • Author(s): 中川伸
  • Total Pages: 256(1-12)
  • Publisher: Research Signpost