2010 Fiscal Year Final Research Report
Invention of immunomodulation with mesenteric stem cells
| Project/Area Number |
20591510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hirosaki University |
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Principal Investigator |
NARUMI Shunji Hirosaki University, 大学院・医学研究科, 准教授 (90250612)
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| Research Collaborator |
KUBO Norithito 弘前大学, 大学院・医学研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫寛容 / 臓器移植 / 間葉系幹細胞 |
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| Research Abstract |
Adipose tissue derived stem cells (ASCs) were successfully separated and purified in mice. Potential of transforming to nerve cells, osteocytes, and cartilage cells were confirmed. Immunomodulation using ASCs have not been established due to pulmonary embolism. Instead, prolongation of survival of mice with ConcanavalinA induced hepatitis were recognized by administration of ASCs. This effect was recognized as dose-related response. New clinical utility of ASC was invented.
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