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2010 Fiscal Year Final Research Report

Role of cancer cell stemness in the development of peritoneal metastasis and drug resistance

Research Project

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Project/Area Number 20591567
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

KODERA Yasuhiro  Nagoya University, 医学系研究科, 准教授 (10345879)

Co-Investigator(Kenkyū-buntansha) NAKAO Akimasa  名古屋大学, 大学院・医学系研究科, 教授 (70167542)
Co-Investigator(Renkei-kenkyūsha) NAKANISHI Hayao  , 愛知県がんセンター腫瘍病理学, 室長 (20207830)
Project Period (FY) 2008 – 2010
Keywords癌幹細胞 / 腹膜転移 / L1 / 増殖能 / 遊走能
Research Abstract

Expression of various candidate stem cell markers was evaluated using clinical specimens from gastric cancer patients. Through this approach, role of stem cells in the formation of peritoneal metastasis was assessed. The expression of one of the markers, L1, was found to be a significant prognosticator. Furthermore, L1 was found to enhance cell proliferation and motility through activation of p-ERK, and several genes including DYRK1A were co-down-regulated by siRNA-mediated inhibition of the L1 expression. On the other hand, analysis of stem cell markers in the clinical specimens did not support the notion that stem cells had a particular role in the formation of peritoneal metastasis, and intractability of peritoneal metastasis may be attributed to other factors.

  • Research Products

    (4 results)

All 2011 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Expression of L1 Cell Adhesion Molecule Is a Significant Prognostic Factor in pT3-stage Gastric Cancer2009

    • Author(s)
      Y. Kodera, H. Nakanishi, S. Ito, K. Misawa, Y. Ito, G. Nakayama, M. Koike, M. Fujiwara, Y. Yamamura, A. Nakao
    • Journal Title

      Anticancer Research 29

      Pages: 4033-4040

    • Peer Reviewed
  • [Presentation] Role of L1 cell adhesion molecule in gastric carcinoma2011

    • Author(s)
      T.Ito, Y.Kodera, C.Tanaka, N.Ohashi, G.Nakayama, M.Koike, M.Fujiwara, H.Nakanishi, A.Nakao
    • Organizer
      2011 ASCO Gastrointestinal Cancers Symposium
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      20110120-20110122
  • [Presentation] 胃癌患者における予後因子としてのL1CAM発現と遺伝子発現の変化について2010

    • Author(s)
      神野敏美、小寺泰弘、藤原道隆、小池聖彦、中山吾郎、中尾昭公
    • Organizer
      第110回日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-10
  • [Presentation] 胃癌患者における短期的予後のマーカーとしてのL1CAM発現について2010

    • Author(s)
      神野敏美、小寺泰弘、藤原道隆、小池聖彦、中尾昭公
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-10

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Published: 2012-01-26   Modified: 2016-04-21  

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