2010 Fiscal Year Final Research Report

A role of FZD10, a WNT receptor, in the colon carcinogenesis.

Research Project

Project/Area Number	20591589
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Kyoto University
Principal Investigator	NAGAYAMA Satoshi Kyoto University, 有明病院消化器外科, 医長 (70362499)
Co-Investigator(Kenkyū-buntansha)	SAKAI Yoshiharu 京都大学, 医学研究科, 教授 (60273455) TOGUCHIDA Junya 京都大学, 再生医科学研究所, 教授 (40273502) KUBO Hajime 京都大学, 医学研究所, 講師 (50362520)
Project Period (FY)	2008 – 2010
Keywords	大腸癌 / 浸潤 / Wnt伝達系 / FZD10
Research Abstract	Since FZD10 is located in plasma membranes as a cell-surface receptor for Wnt ligands and its expression is very low or absent in vital organs, we have focused on this molecule as a likely candidate for antibody-based therapy. We investigated the immunohistochemical expression patterns of FZD10 in tissue samples derived from patients with colorectal cancers. There was no immunoreactivity for FZD10 in normal colonic mucosa or normal liver parenchyma, whereas cancer cells in the primary and metastatic lesions showed an increased level of FZD10 expression. These results suggest that FZD10 may play a role in the progression of colorectal cancers and can be a promising candidate for a novel therapy of metastatic liver lesions from colorectal cancers.