2010 Fiscal Year Final Research Report
The prophylactic effect of pulmonary vein isolation on the occurrence of atrial fibrillation in a left atrial volume load canine model
| Project/Area Number |
20591660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
NITTA Takashi Nippon Medical School, 医学部, 教授 (40256954)
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| Co-Investigator(Kenkyū-buntansha) |
ISGI Yosuke 日本医科大学, 医学部, 講師 (10307895)
OMORI Hiroya 日本医科大学, 医学部, 助教 (40343587)
SAKAMOTO Shun-Ichiro 日本医科大学, 医学部, 助教 (50398872)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心房細動 / 肺静脈 / 容量負荷 |
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| Research Abstract |
To test if prophylactic pulmonary vein isolation prevents development of atrial fibrillation, the left atrial antrum circular ablation was performed by a bipolar radiofrequency ablation device in a subclavian artery - pulmonary artery canine model. The left atrial dimension was progressively increased. The atrial activation cycles were progressively shortened, particularly in the left atrium. During atrial fibrillation, focal rapid activations were observed at the superior pulmonary veins. These activations were blocked by the pulmonary vein isolation.
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