2010 Fiscal Year Final Research Report
Identification of epigenetic biomarkers in benign brain tumors in the post-genome era
| Project/Area Number |
20591710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University |
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Principal Investigator |
SAITO Kiyoshi Nagoya University, 医学部, 教授 (00240804)
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| Co-Investigator(Kenkyū-buntansha) |
NATSUME Atsushi 名古屋大学, 大学院・医学系研究科, 准教授 (30362255)
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| Research Collaborator |
ITO Eiji 福島医科大学, 医学部, 助教 (30402605)
KISHIDA Yugo 名古屋大学, 大学院・医学系研究科, 大学院
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| Project Period (FY) |
2008 – 2010
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| Keywords | 良性脳腫瘍 / 髄膜腫 / エピジェネティクス / マイクロアレイ / DNAメチル化 / バイオマーカー |
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| Research Abstract |
We analyzed exhaustive epigenetic changes of the meningioma, the most common brain tumor. Using microarrays that can analyze 6157 genomes, 15273 CpG islands, 20 WHO grade 1 and 10 grade 2 meningiomas were analyzed. The data showed 2 clusters, hypo-methylated and hyper-methylated groups, independent of WHO grading. Most invasive meningiomas and recurrent meningiomas were included in the hyper-methylated cluster. Our results suggest that epigenetic changes of DNA methylation reflect active nature, such as invasion or recurrence, of the meningiomas.
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[Journal Article] Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells.2010
Author(s)
Kato T, Natsume A, Toda H, Iwamizu H, Sugita T, Hachisu R, Watanabe R, Yuki K, Motomura K, Bankiewicz K, Wakabayashi T
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Journal Title
Gene Therapy 17
Pages: 1363-1371
Peer Reviewed
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